INT334438

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.37
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 24 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
abdominal pain 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 348 98.48 Very High Very High Very High
Fever 30 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Syndrome 18 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Hypergammaglobulinemia 6 5.00 Very Low Very Low Very Low
Dementia 6 5.00 Very Low Very Low Very Low
Frailty 6 5.00 Very Low Very Low Very Low
Headache 6 5.00 Very Low Very Low Very Low
Ataxia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the same approach, i.e., reducing the flux through the pathway by incubating control and MKD cells with simvastatin, an inhibitor of HMG-CoA reductase, we now studied the effect on localization and activation of RhoA and Rac1.
Positive_regulation (activation) of Localization (localization) of Rac1 associated with mevalonate kinase deficiency
1) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.65 Pain Relevance 0
To confirm that the observed effect of simvastatin on RhoA and Rac1 activation was due to a shortage of GGPP, we studied the effect of GGTI, an inhibitor of geranylgeranyl transferase, on localization and activation of RhoA and Rac1 and found that GGTI had a similar effect as simvastatin.
Positive_regulation (activation) of Localization (localization) of Rac1
2) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.29 Pain Relevance 0
Effect of simvastatin on RhoA and Rac1 localization and activation
Positive_regulation (activation) of Localization (localization) of Rac1
3) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.23 Pain Relevance 0
The effect of GGTI on RhoA and Rac1 localization and activation
Positive_regulation (activation) of Localization (localization) of Rac1
4) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.18 Pain Relevance 0
Fig. 1Effect of simvastatin on the localization and activation of RhoA (a–e) and Rac1 (f–j).
Positive_regulation (activation) of Localization (localization) of Rac1
5) Confidence 0.29 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.78 Pain Relevance 0
Fig. 2Effect of geranylgeranyltransferase inhibitor (GGTI) on the localization and activation of RhoA (a–e) and Rac1 (f–j).
Positive_regulation (activation) of Localization (localization) of Rac1
6) Confidence 0.29 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.25 Pain Relevance 0

General Comments

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