INT334440

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.18
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mvk) mRNA binding (Mvk) peroxisome (Mvk)
kinase activity (Mvk) cytoplasm (Mvk)
Mvk (Mus musculus)
Pain Link Frequency Relevance Heat
headache 2 67.76 Quite High
abdominal pain 2 66.08 Quite High
Arthritis 2 64.80 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 116 98.98 Very High Very High Very High
Hypergammaglobulinemia 2 79.92 Quite High
Fever 10 76.80 Quite High
Syndrome 6 75.36 Quite High
Headache 2 67.76 Quite High
Exanthema 2 66.96 Quite High
Abdominal Pain 2 66.08 Quite High
Arthritis 2 64.80 Quite High
Vomiting 2 63.92 Quite High
Diarrhoea 2 62.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MKD is due to mutations in the MVK gene, resulting in decreased activities of mevalonate kinase (MK; EC 2.7.1.36), the first enzyme following the highly regulated 3-hydroxy-3-methylgluaryl (HMG-CoA reductase) in the isoprenoid biosynthesis pathway (Houten et al 2003a; Waterham 2006).
Negative_regulation (decreased) of Transcription (activities) of mevalonate kinase associated with mevalonate kinase deficiency
1) Confidence 0.27 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 1.09 Pain Relevance 0.17
MKD is due to mutations in the MVK gene, resulting in decreased activities of mevalonate kinase (MK; EC 2.7.1.36), the first enzyme following the highly regulated 3-hydroxy-3-methylgluaryl (HMG-CoA reductase) in the isoprenoid biosynthesis pathway (Houten et al 2003a; Waterham 2006).
Negative_regulation (decreased) of Transcription (activities) of MK associated with mevalonate kinase deficiency
2) Confidence 0.27 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 1.09 Pain Relevance 0.17

General Comments

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