INT334443

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.10
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 84.96 Quite High
Arthritis 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 58 99.84 Very High Very High Very High
Syndrome 3 91.76 High High
INFLAMMATION 4 84.96 Quite High
Fever 5 81.76 Quite High
Arthritis 1 5.00 Very Low Very Low Very Low
Hypergammaglobulinemia 1 5.00 Very Low Very Low Very Low
Dementia 1 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low
Ataxia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, we showed that protein isoprenylation in MKD cells is more sensitive to inhibition by simvastatin than in control cells, resulting in an increased, ectopic activation of soluble RhoA and Rac1 in MKD cells.
Positive_regulation (increased) of Positive_regulation (activation) of Rac1 associated with mevalonate kinase deficiency
1) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 1.10 Pain Relevance 0.08

General Comments

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