INT334445

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.73
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 89.68 High High
Arthritis 3 41.96 Quite Low
abdominal pain 3 41.52 Quite Low
headache 3 40.44 Quite Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 174 98.48 Very High Very High Very High
Fever 15 92.40 High High
INFLAMMATION 12 89.68 High High
Dementia 3 50.64 Quite High
Frailty 3 49.48 Quite Low
Ataxia 3 48.68 Quite Low
Diarrhoea 3 42.88 Quite Low
Vomiting 3 42.28 Quite Low
Arthritis 3 41.96 Quite Low
Abdominal Pain 3 41.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because small GTPases depend on isoprenylation for their proper signalling function, we studied the effect of MK deficiency on isoprenylation (i.e., geranylgeranylation) and activation of the two small GTPases, RhoA and Rac1.
Regulation (effect) of Positive_regulation (activation) of Rac1
1) Confidence 0.40 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.58 Pain Relevance 0.04
Because small guanosine triphosphatases (GTPases) depend on geranylgeranylation for their proper signaling function, we studied the effect of MK deficiency on geranylgeranylation and activation of the two small GTPases, RhoA and Rac1.
Regulation (effect) of Positive_regulation (activation) of Rac1
2) Confidence 0.18 Published 2010 Journal J Inherit Metab Dis Section Abstract Doc Link PMC2946549 Disease Relevance 0.50 Pain Relevance 0
Using the same approach, i.e., reducing the flux through the pathway by incubating control and MKD cells with simvastatin, an inhibitor of HMG-CoA reductase, we now studied the effect on localization and activation of RhoA and Rac1.
Regulation (effect) of Positive_regulation (activation) of Rac1 associated with mevalonate kinase deficiency
3) Confidence 0.18 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.65 Pain Relevance 0

General Comments

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