INT334473

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
PGGT1B (Homo sapiens)
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 116 95.32 Very High Very High Very High
Fever 10 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Hypergammaglobulinemia 2 5.00 Very Low Very Low Very Low
Dementia 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Headache 2 5.00 Very Low Very Low Very Low
Ataxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm that the observed effect of simvastatin on RhoA and Rac1 activation was due to a shortage of GGPP, we studied the effect of GGTI, an inhibitor of geranylgeranyl transferase, on localization and activation of RhoA and Rac1 and found that GGTI had a similar effect as simvastatin.
GGTI Regulation (effect) of Localization (localization) of RhoA
1) Confidence 0.04 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.29 Pain Relevance 0
The effect of GGTI on RhoA and Rac1 localization and activation
GGTI Regulation (effect) of Localization (localization) of RhoA
2) Confidence 0.02 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.18 Pain Relevance 0

General Comments

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