INT334504

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 7.97
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dendritic cells 5
monocytes 1
basophils 1
mast cells 1
IGHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 60 91.52 High High
corticosteroid 24 71.16 Quite High
Onset of action 4 47.48 Quite Low
Pain 4 44.20 Quite Low
headache 4 43.56 Quite Low
pruritus 4 42.20 Quite Low
antagonist 16 39.20 Quite Low
cytokine 56 30.88 Quite Low
agonist 28 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaphylaxis 12 96.80 Very High Very High Very High
Drug Hypersensitivity 4 95.68 Very High Very High Very High
Nasal Polyps 4 95.12 Very High Very High Very High
Sinusitis 4 94.04 High High
Hyperplasia 4 93.64 High High
Latex Hypersensitivity 4 92.76 High High
Pulmonary Aspergillosis 4 92.16 High High
Pneumonia 4 91.92 High High
Hypersensitivity 112 90.88 High High
Urticaria 4 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Omalizumab decreases free IgE levels rapidly and the expression of the high affinity IgE receptor expression on key effector cells, including mast cells, basophils, dendritic cells and monocytes.
Regulation (affinity) of Transcription (expression) of IgE in dendritic cells
1) Confidence 0.29 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 1.99 Pain Relevance 0.14
Omalizumab decreases free IgE levels rapidly and the expression of the high affinity IgE receptor expression on key effector cells, including mast cells, basophils, dendritic cells and monocytes.
Regulation (affinity) of in mast cells Transcription (expression) of IgE in dendritic cells
2) Confidence 0.10 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 1.99 Pain Relevance 0.14
Omalizumab decreases free IgE levels rapidly and the expression of the high affinity IgE receptor expression on key effector cells, including mast cells, basophils, dendritic cells and monocytes.
Regulation (affinity) of in monocytes Transcription (expression) of IgE in dendritic cells
3) Confidence 0.10 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 1.99 Pain Relevance 0.14
Omalizumab decreases free IgE levels rapidly and the expression of the high affinity IgE receptor expression on key effector cells, including mast cells, basophils, dendritic cells and monocytes.
Regulation (affinity) of in basophils Transcription (expression) of IgE in dendritic cells
4) Confidence 0.10 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 1.99 Pain Relevance 0.14

General Comments

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