INT334520

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.09
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxq1) embryo development (Foxq1) DNA binding (Foxq1)
transcription factor binding (Foxq1)
Anatomy Link Frequency
skin 2
Foxq1 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 2 81.12 Quite High
Nerve growth factor 98 65.92 Quite High
Inflammation 14 31.44 Quite Low
c fibre 6 25.00 Low Low
substance P 16 5.00 Very Low Very Low Very Low
qutenza 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Antihistamine 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eczema 216 99.84 Very High Very High Very High
Pruritus 48 62.44 Quite High
Congenital Anomalies 8 57.68 Quite High
Hypersensitivity 8 55.40 Quite High
Adhesions 2 51.88 Quite High
Skin Diseases 6 31.96 Quite Low
INFLAMMATION 10 31.44 Quite Low
Disease 8 25.00 Low Low
Erythema 6 25.00 Low Low
Papular Skin Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the number of SA colonies on the skin surface and the serum IL-18 levels in patients with AD significantly correlated with the skin scores of AD lesions.
Regulation (colonies) of SA in skin associated with eczema
1) Confidence 0.06 Published 2010 Journal Allergy, Asthma & Immunology Research Section Abstract Doc Link PMC2946701 Disease Relevance 0.74 Pain Relevance 0
Therefore, the measurement of TEWL in the skin is useful for early diagnosis of infantile AD and the early care on the skin of these infants might be expected to effect protectively on development and aggravation of AD.1 We have already reported that Staphylococcus aureus (SA) usually existed not only on the skin regions affected by AD but also on the atopic dry skin regions.2 The number of SA detected on the skin surface of forearm and forehead in AD patients was remarkably more than that in healthy controls, as shown Fig. 1.2 There was a significant correlation between eruption score and the number of SA detected on the same area of patients with AD (relationship coefficiency= 0.54, P<0.01),1 as shown in Fig. 2.3 We have also reported that farnesol (F) of a perfume and xylitol (X) of sugar alcohol synergistically can inhibit the biofilm formation of SA and moreover can dissolve the formed biofilm of SA, as shown in Fig. 3-1 and Fig. 3-2.3,4 Indeed, the treatment with FX cream improved significantly 4 out of 5 items in AD lesions at 2 weeks later, while the treatment with control cream improved only 1 item of dryness/desquamation as shown in Fig. 4.3,4 Both of the number of SA and the ratio of SA to total bacteria at the sites, to which the FX cream containing F and X had been applied, significantly decreased in 2 weeks later, accompanied with clinical improvement of AD, as shown in Fig. 5.3,4 The therapeutic effect of this FX cream is conceivable to be based on two functions of it, namely the prevention of adhesion of SA to the skin and the removal of SA from the skin.
Regulation (affected) of SA in skin associated with eczema, adhesions and alcohol
2) Confidence 0.03 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 1.35 Pain Relevance 0.11

General Comments

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