INT334525

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.93
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nrp1) cytosol (Nrp1) signal transduction (Ngf)
extracellular space (Ngf) extracellular region (Ngf) cell adhesion (Nrp1)
Anatomy Link Frequency
growth cone 2
Ngf (Mus musculus)
Nrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 49 100.00 Very High Very High Very High
Inflammation 7 62.64 Quite High
Antinociceptive 1 20.36 Low Low
Pain 1 9.72 Low Low
substance P 8 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
c fibre 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Antihistamine 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eczema 108 99.80 Very High Very High Very High
Shock 1 96.88 Very High Very High Very High
Pruritus 24 79.12 Quite High
Acanthosis 2 69.28 Quite High
INFLAMMATION 5 62.64 Quite High
Skin Diseases 3 46.16 Quite Low
Congenital Anomalies 4 19.60 Low Low
Disease 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Erythema 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the combination therapy of Sema3A with anti-NGF antibody may not be justified for AD, because NGF is known to increase the expression levels of NRP-157 and to augment the effect of Sema3A to induce axon repulsion (or growth cone collapse) of dorsal root ganglia neurons.58 Further studies should be required to elucidate the mechanism of action of Sema3A on AD.
NGF Positive_regulation (increase) of Gene_expression (expression) of NRP-157 in growth cone associated with nerve growth factor, shock and eczema
1) Confidence 0.19 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.93 Pain Relevance 0.22

General Comments

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