INT334526

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sema3a) cytosol (Trpv1) transport (Trpv1)
extracellular region (Sema3a) plasma membrane (Trpv1) transmembrane transport (Trpv1)
Anatomy Link Frequency
nerve 2
Trpv1 (Mus musculus)
Sema3a (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 100.00 Very High Very High Very High
qutenza 3 98.30 Very High Very High Very High
Antinociceptive 1 90.00 High High
vanilloid receptor subtype 1 1 85.32 High High
Inflammation 7 81.88 Quite High
Nerve growth factor 49 5.00 Very Low Very Low Very Low
substance P 8 5.00 Very Low Very Low Very Low
c fibre 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Antihistamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eczema 108 93.68 High High
Pruritus 24 92.08 High High
Congenital Anomalies 4 91.36 High High
INFLAMMATION 5 81.88 Quite High
Recurrence 1 41.80 Quite Low
Acanthosis 2 7.60 Low Low
Disease 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Erythema 3 5.00 Very Low Very Low Very Low
Skin Diseases 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the most notorious clinical limitation of capsaicin application is supposed to be acute excitation of the sensory C-afferents, which is induced by the TRPV1 and results in a remarkable "hot painful burning" sensation.36 Does reduction in innervation density of intraepidermal nerve fibers by the local application of Sema3A cause such a sensation?
TRPV1 Positive_regulation (induced) of Gene_expression (application) of Sema3A in nerve associated with pain and qutenza
1) Confidence 0.31 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.92 Pain Relevance 0.55

General Comments

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