INT334529

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) signal transduction (Ngf) extracellular space (Ngf)
extracellular region (Ngf) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
peripheral nervous system 2
Pax3 (Mus musculus)
Ngf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 49 100.00 Very High Very High Very High
substance P 8 100.00 Very High Very High Very High
Peripheral nervous system 1 99.96 Very High Very High Very High
cytokine 2 99.80 Very High Very High Very High
antagonist 1 67.36 Quite High
Antihistamine 2 59.20 Quite High
Inflammation 7 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
c fibre 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eczema 108 94.14 High High
Contact Dermatitis 1 87.84 High High
Pruritus 24 42.48 Quite Low
Lichen 2 34.60 Quite Low
Papular Skin Disease 2 33.32 Quite Low
Erythema 3 33.00 Quite Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, we have already reported that olopatadine suppresses the increase of SP levels in the skin lesions induced by the repeated application of 2,4,6-trinitrochlorbenzane in DSNh of atopic model mouse.25 In AD patients, too, it has been reported that olopatadine significantly decreased the serum SP level because of down-modulatory effect on tachykinin release.26 Other studies have also shown that whereas NGF stimulates the synthesis and releases of SP in the central and peripheral nervous system, SP induces NGF synthesis via cytokines, too.27,28 These results suggest that the activations of NGF and SP are interdependent.
SP Positive_regulation (induces) of Gene_expression (synthesis) of NGF in peripheral nervous system associated with peripheral nervous system, nerve growth factor, eczema, cytokine and substance p
1) Confidence 0.03 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.31 Pain Relevance 0.91

General Comments

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