INT334543

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (LRP5) plasma membrane (LRP5)
LRP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 96.20 Very High Very High Very High
Inflammation 12 96.00 Very High Very High Very High
depression 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 96.00 Very High Very High Very High
Osteoporosis 30 94.40 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 128 92.88 High High
Infection 64 75.04 Quite High
Hypercalcemia 16 56.64 Quite High
Aging 24 50.00 Quite Low
Apoptosis 4 37.56 Quite Low
Viral Infection 2 22.40 Low Low
Parkinson's Disease 6 5.00 Very Low Very Low Very Low
Phosphate Metabolism Disorders 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several of the HIV protease inhibitors have been shown to alter bone mineral density.50 Recent gene expression profiling has indicated that exposure of osteoblastic cells to nelfinavir and ritonavir increases gene expression of the inflammatory cytokines, MCP-1, and interleukin-8.51 Protease inhibitors have also been suggested to inhibit 1-alpha-hydroxylase, as well as to reduce 1,25(OH)2D levels, which could reduce bone mineral density.45 LRP5, a positive regulator of bone formation, is inhibited by protease inhibitors.51,52
Negative_regulation (positive) of Positive_regulation (regulator) of LRP5 associated with inflammation, acquired immune deficiency syndrome or hiv infection, osteoporosis and cytokine
1) Confidence 0.23 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946855 Disease Relevance 0.90 Pain Relevance 0.12
Several of the HIV protease inhibitors have been shown to alter bone mineral density.50 Recent gene expression profiling has indicated that exposure of osteoblastic cells to nelfinavir and ritonavir increases gene expression of the inflammatory cytokines, MCP-1, and interleukin-8.51 Protease inhibitors have also been suggested to inhibit 1-alpha-hydroxylase, as well as to reduce 1,25(OH)2D levels, which could reduce bone mineral density.45 LRP5, a positive regulator of bone formation, is inhibited by protease inhibitors.51,52
Negative_regulation (inhibited) of Positive_regulation (regulator) of LRP5 associated with inflammation, acquired immune deficiency syndrome or hiv infection, osteoporosis and cytokine
2) Confidence 0.23 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946855 Disease Relevance 0.91 Pain Relevance 0.12

General Comments

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