INT334607

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.50
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MRGPRD) signal transducer activity (MRGPRD)
Anatomy Link Frequency
neurons 2
MRGPRD (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 36 99.80 Very High Very High Very High
agonist 234 99.76 Very High Very High Very High
potassium channel 6 99.32 Very High Very High Very High
Pain 78 98.12 Very High Very High Very High
GABA receptor 6 96.08 Very High Very High Very High
gABA 54 95.84 Very High Very High Very High
Neurotransmitter 12 91.96 High High
antagonist 168 82.72 Quite High
Gabapentin 6 60.64 Quite High
pregabalin 6 59.44 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 36 99.80 Very High Very High Very High
Pain 84 98.12 Very High Very High Very High
Nociception 42 95.00 High High
Targeted Disruption 6 54.44 Quite High
Disease 6 42.84 Quite Low
Bordatella Infection 6 17.28 Low Low
Cancer 12 5.00 Very Low Very Low Very Low
Communicable Diseases 6 5.00 Very Low Very Low Very Low
Schizophrenia 6 5.00 Very Low Very Low Very Low
Psychosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, this observation may differ across cell types, since in DRG neurons, inhibition of the M current by beta-alanine activated MrgD occurs primarily through the Gi pathway [14].
beta-alanine Neg (inhibition) Binding (inhibition) of in neurons associated with dorsal root ganglion
1) Confidence 0.34 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2947157 Disease Relevance 0.10 Pain Relevance 0.20
We have observed a novel interaction between MrgD and KCNQ/M-type potassium channels that results in suppression of these channels and enhancement of the excitability of DRG neurons [14].
MrgD Binding (interaction) of in neurons associated with dorsal root ganglion and potassium channel
2) Confidence 0.34 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2947157 Disease Relevance 0.74 Pain Relevance 0.74
Eliminating compounds that induced calcium mobilization in the parental line ensured that the agonists identified interact specifically with MrgD.
MrgD Binding (interact) of associated with agonist
3) Confidence 0.32 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2947157 Disease Relevance 0 Pain Relevance 0.36
The beta-alanine EC50 values obtained for both human and rat MrgD cell lines were in the1–4??
MrgD Binding (lines) of
4) Confidence 0.29 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2947157 Disease Relevance 0 Pain Relevance 0.30
As a result of the promiscuous interaction of beta-alanine with other receptors precise interpretation of the in vivo studies leading to insight regarding the role of beta-alanine in nociception is confounded.
beta-alanine Binding (interaction) of associated with nociception
5) Confidence 0.28 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2947157 Disease Relevance 0.27 Pain Relevance 0.46
It has been reported that beta-alanine decreases glutamatergic excitation by binding to, and thus competing for, the glycine co-agonist site of the N-methyl-D-aspartate (NMDA) receptor [16, 17].
beta-alanine Binding (binding) of associated with agonist
6) Confidence 0.28 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2947157 Disease Relevance 0.39 Pain Relevance 0.53

General Comments

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