INT334621

Context Info Confidence 0.65 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.86 Pain Relevance 0.34

transport (Kcna2) transmembrane transport (Kcna2)

Kcna2 (Mus musculus)

Pain Link Frequency Relevance Heat Demyelination 26 98.92 potassium channel 1 94.16 Nav1.6 11 70.32 Action potential 29 45.68 Multiple sclerosis 28 34.76 Inflammation 20 5.00 Spinal cord 18 5.00 Dorsal column 5 5.00 Hippocampus 5 5.00 isoflurane 3 5.00

Disease Link Frequency Relevance Heat Multiple Sclerosis 217 99.38 Demyelinating Disease 59 98.92 Cognitive Disorder 3 57.52 Disease 28 5.00 INFLAMMATION 21 5.00 Alzheimer's Dementia 10 5.00 Targeted Disruption 4 5.00 Leukemia 3 5.00 Congenital Anomalies 3 5.00 Bordatella Infection 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Demyelination in vehicle-treated EAE was associated with increased expression of Kv1.2 and a lengthening of Kv1.2 immunostaining across the entire axon length.

Gene_expression (expression) of Kv1.2 associated with multiple sclerosis and demyelination

1) Confidence 0.65 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.86 Pain Relevance 0.34

General Comments

This test has worked.