INT334631

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Igf1r, Akt1) kinase activity (Igf1r, Akt1) transport (Akt1)
aging (Akt1) enzyme binding (Akt1) carbohydrate metabolic process (Akt1)
Anatomy Link Frequency
oligodendrocyte 2
Igf1r (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 26 98.64 Very High Very High Very High
dorsal root ganglion 1 69.96 Quite High
Multiple sclerosis 28 56.48 Quite High
Inflammation 20 53.44 Quite High
Action potential 29 5.00 Very Low Very Low Very Low
Spinal cord 18 5.00 Very Low Very Low Very Low
Nav1.6 11 5.00 Very Low Very Low Very Low
Dorsal column 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 59 98.64 Very High Very High Very High
Cv Unclassified Under Development 1 73.60 Quite High
Multiple Sclerosis 217 71.12 Quite High
Ganglion Cysts 1 69.96 Quite High
INFLAMMATION 21 53.44 Quite High
Recurrence 2 36.72 Quite Low
Disease Progression 2 24.96 Low Low
Disease 28 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 10 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, the insulin-like growth factor-1 receptor promotes sustained phosphorylation of serine/threonine-specific protein kinases (Akt), which is required for the survival of oligodendrocyte progenitors (Pang et al., 2007; Romanelli et al., 2009).
insulin-like growth factor-1 receptor Positive_regulation (promotes) of Phosphorylation (phosphorylation) of Akt in oligodendrocyte
1) Confidence 0.19 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.50 Pain Relevance 0.18

General Comments

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