INT33466

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Context Info
Confidence 0.43
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 9.06
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4B) extracellular region (C4B)
Anatomy Link Frequency
muscle 1
cleavage 1
shoulder 1
nerve 1
proximal 1
C4B (Homo sapiens)
Pain Link Frequency Relevance Heat
Cluster headache 340 100.00 Very High Very High Very High
local anesthetic 8 99.36 Very High Very High Very High
headache 116 92.96 High High
abdominal pain 6 90.00 High High
Pain 68 87.44 High High
Acupuncture 2 86.52 High High
spinal inflammation 1 80.24 Quite High
Deep tissue 6 79.60 Quite High
Triptan 16 66.24 Quite High
Trigeminal neuralgia 10 63.80 Quite High
Disease Link Frequency Relevance Heat
Cluster Headache 344 100.00 Very High Very High Very High
Pituitary Cancer 4 100.00 Very High Very High Very High
Iron Overload 2 99.70 Very High Very High Very High
Aging 2 99.68 Very High Very High Very High
Systemic Lupus Erythematosus 12 99.36 Very High Very High Very High
Syndrome 13 99.28 Very High Very High Very High
Metastasis 7 98.28 Very High Very High Very High
Paralysis 6 98.24 Very High Very High Very High
Disease 74 98.12 Very High Very High Very High
Carcinoma 2 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven are linked to the HL-A region: six are recessive (idiopathic hemochromatosis, C2, C4A, and C4B deficiencies, congenital and late-onset deficiencies) and one is dominant (spinocerebellar ataxia).
Negative_regulation (deficiencies) of C4B associated with spinocerebellar ataxia type 2 and iron overload
1) Confidence 0.43 Published 1986 Journal Adv. Nephrol. Necker Hosp. Section Abstract Doc Link 3006451 Disease Relevance 0.76 Pain Relevance 0.08
Variable copy number of the complement component C4 (C4A and C4B) leads to different susceptibilities to SLE [67,68].
Negative_regulation (number) of C4B associated with systemic lupus erythematosus
2) Confidence 0.30 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2039766 Disease Relevance 0.88 Pain Relevance 0
The reports on patients who developed CH in their 70ies and 80ies demonstrate that higher age does not prevent the development of CH.
Negative_regulation (developed) of CH associated with cluster headache
3) Confidence 0.19 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1079865 Disease Relevance 1.56 Pain Relevance 1.56
C4bp acts as a co-factor for CFI, catalyzing the cleavage and inactivation of C4b [25].
Negative_regulation (inactivation) of C4b in cleavage
4) Confidence 0.15 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0
With aging, attacks often decrease and active CH is rarely seen after age of 75 years.


Negative_regulation (decrease) of CH associated with cluster headache and aging
5) Confidence 0.12 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2517059 Disease Relevance 1.28 Pain Relevance 0.99
There seems to be an overrepresentation of pituitary tumors in CH patients [44], and a role of prolactin has been suggested in these cases.
Negative_regulation (overrepresentation) of CH in pituitary associated with cluster headache and pituitary cancer
6) Confidence 0.12 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2517059 Disease Relevance 2.60 Pain Relevance 1.48
Investigations were consistent with type 1 HAE, showing low C1 esterase inhibitor activity of 0.06 g/litre (normal range [NR] 0.2 to 0.65 g/litre), low complement C4 and normal complement C3.
Negative_regulation (inhibitor) of complement C4
7) Confidence 0.12 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2577685 Disease Relevance 1.45 Pain Relevance 0.23
[Clinical experience in interscalene brachial plexus block combined with Ho's method of C3-4 block for shoulder and proximal upper extremity surgeries].
Negative_regulation (block) of C3-4 in upper
8) Confidence 0.02 Published 1996 Journal Acta Anaesthesiol. Sin. Section Title Doc Link 9084537 Disease Relevance 0.17 Pain Relevance 0.13
The Ho's point which circumscribes the landmark for C3-4 block is a point at which the outer margin of the external jugular vein intersects the sternocleidomastoid muscle.
Negative_regulation (block) of C3-4 in muscle
9) Confidence 0.02 Published 1996 Journal Acta Anaesthesiol. Sin. Section Body Doc Link 9084537 Disease Relevance 0 Pain Relevance 0
If high volume of local anesthetic (40 ml) is used to block C3-4, complications like Horner's syndrome and phenic nerve palsy would be frequent.
Negative_regulation (block) of C3-4 in nerve associated with syndrome, paralysis and local anesthetic
10) Confidence 0.02 Published 1996 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 9084537 Disease Relevance 0.20 Pain Relevance 0.14
CONCLUSIONS: Interscalene brachial plexus block combined with Ho's method of C3-4 block is technically safe and economical for patients receiving shoulder and proximal third of upper extremity surgery.
Negative_regulation (block) of C3-4 in proximal
11) Confidence 0.02 Published 1996 Journal Acta Anaesthesiol. Sin. Section Body Doc Link 9084537 Disease Relevance 0 Pain Relevance 0
We used 0.5% bupivacaine 10 ml combined with 2% lidocaine 10 ml for interscalene brachial plexus block and 2% lidocaine 10 ml only for C3-4 block.
Negative_regulation (block) of C3-4 in brachial plexus
12) Confidence 0.02 Published 1996 Journal Acta Anaesthesiol. Sin. Section Body Doc Link 9084537 Disease Relevance 0 Pain Relevance 0
C4-2B cells were depleted from steroids, and treated with DHT or vehicle for 0, 2, 4, 8, 16, 24 or 48 hours.
Negative_regulation (depleted) of C4-2B
13) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.17 Pain Relevance 0.03
CONCLUSIONS: Interscalene brachial plexus block combined with Ho's method of C3-4 block is technically safe and economical for patients receiving shoulder and proximal third of upper extremity surgery.
Negative_regulation (block) of C3-4 in shoulder
14) Confidence 0.01 Published 1996 Journal Acta Anaesthesiol. Sin. Section Body Doc Link 9084537 Disease Relevance 0 Pain Relevance 0

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