INT33474

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Context Info
Confidence 0.13
First Reported 1983
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.02
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r) plasma membrane (Ltb4r) signal transducer activity (Ltb4r)
Anatomy Link Frequency
PMN 2
endothelial cell 1
leukocyte 1
Ltb4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 42 99.36 Very High Very High Very High
aspirin 7 99.04 Very High Very High Very High
dexamethasone 6 99.02 Very High Very High Very High
Endogenous opioid 1 98.68 Very High Very High Very High
cINOD 12 94.24 High High
Potency 1 93.64 High High
Arthritis 2 93.36 High High
Antinociceptive 2 91.60 High High
narcan 2 90.16 High High
Pain threshold 1 89.76 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 5 99.92 Very High Very High Very High
INFLAMMATION 37 99.36 Very High Very High Very High
Adhesions 1 96.92 Very High Very High Very High
Arthritis 2 93.36 High High
Pain 6 89.76 High High
Hyperalgesia 4 78.72 Quite High
Nociception 4 75.00 Quite High
Gastritis 2 75.00 Quite High
Hypoalagesia 2 69.68 Quite High
Erythema 1 68.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of LTB4 may, in part, account for the lower number of cells in the exudate since LTB4 is a potent leukotactic agent.
Negative_regulation (inhibition) of LTB4
1) Confidence 0.13 Published 1983 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6141244 Disease Relevance 0.31 Pain Relevance 0.22
These results suggest that the protective effects of PF-10040 are not attributable to scavenging of free radicals, inhibition of leukotriene synthesis, blockade of LTB4 or LTD4 receptors or inhibition of LTB4-mediated leukocyte endothelial cell adhesion.
Negative_regulation (blockade) of LTB4 in endothelial cell associated with adhesions
2) Confidence 0.11 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8400119 Disease Relevance 0.23 Pain Relevance 0.17
This suggests that reduction of PMN accumulation by indomethacin and flurbiprofen is mediated by a mechanism other than inhibition of LTB4-synthesis.
Negative_regulation (inhibition) of LTB4 in PMN
3) Confidence 0.09 Published 1983 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6141244 Disease Relevance 0.37 Pain Relevance 0.53
As with BW755C, there was a differential effect on PMN and LTB4: dexamethasone (1 mg kg-1) reduced PMN accumulation by 40% but LTB4 formation was inhibited by 70%.
Negative_regulation (inhibited) of LTB4 in PMN associated with dexamethasone
4) Confidence 0.08 Published 1983 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6141244 Disease Relevance 0.40 Pain Relevance 0.54
Inhibition of the LTB4 biosynthetic enzyme 5-lipoxygenase inhibited toxin A-induced increases in ileal LTB4 levels and toxin A- but not LTB4-induced ileitis.
Negative_regulation (Inhibition) of LTB4
5) Confidence 0.07 Published 2005 Journal Gastroenterology Section Body Doc Link 15887113 Disease Relevance 0 Pain Relevance 0
Time course studies demonstrated that the inhibitor effects of BW755C and phenidone on leukocyte recruitment reflected a reduction in the PGE2 but not the LTB4 content of the inflammatory exudate.
Negative_regulation (reduction) of LTB4 in leukocyte associated with inflammation
6) Confidence 0.06 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3011012 Disease Relevance 0.50 Pain Relevance 0.39
This effect is associated with reduced cell infiltration and inhibition of TNF-alpha and LTB4 release and is not linked to an endogenous opioid-release mechanism.
Negative_regulation (inhibition) of LTB4 associated with endogenous opioid
7) Confidence 0.06 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16789926 Disease Relevance 0.53 Pain Relevance 0.43
Supplementation of a standard rat diet with 240 mg/kg/day EPA for 4 weeks significantly decreased the concentration of PGE2 and TXB2 in inflammatory exudate derived from implantation of carrageenin impregnated sponges: neither the concentration of LTB4 nor the cell number were reduced significantly.
Negative_regulation (reduced) of LTB4 associated with inflammation
8) Confidence 0.04 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3006690 Disease Relevance 0.62 Pain Relevance 0.27
LTB4 was found to reduce significantly the yeast edema and this reduction could be reversed by administration PGE1.
Negative_regulation (reduce) of LTB4 associated with pressure and volume under development
9) Confidence 0.00 Published 1983 Journal Prostaglandins Section Abstract Doc Link 6304817 Disease Relevance 1.06 Pain Relevance 0.74

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