INT33475

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Context Info
Confidence 0.58
First Reported 1981
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.45
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ltb)
Ltb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 15 94.48 High High
cINOD 3 92.80 High High
Analgesic 1 88.92 High High
antagonist 2 88.04 High High
agonist 4 87.00 High High
Inflammatory response 1 76.32 Quite High
Hyperalgesia 1 63.80 Quite High
COX2 2 25.00 Low Low
cOX1 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 6 99.82 Very High Very High Very High
Pressure And Volume Under Development 3 98.16 Very High Very High Very High
INFLAMMATION 18 94.48 High High
Ulcers 1 92.96 High High
Stroke 8 88.48 High High
Leukemia 1 71.48 Quite High
Hyperalgesia 1 63.80 Quite High
Erythema 1 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in the presence of the calcium ionophore, A23187, or the non-ionic detergent, BRIJ 56, these cells also produce 5-HETE and LTB.
Gene_expression (produce) of LTB
1) Confidence 0.58 Published 1981 Journal Prostaglandins Section Abstract Doc Link 6259697 Disease Relevance 0.09 Pain Relevance 0.09
Rosiglitazone also increased cerebral lipoxin A(4) (LXA(4)) levels and inhibited MCAO-induced production of leukotriene B4 (LTB(4)).
Gene_expression (production) of LTB associated with middle cerebral artery infarction
2) Confidence 0.52 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321784 Disease Relevance 0.69 Pain Relevance 0.20
Altogether, our data illustrate that some effects of rosiglitazone are attributable to de novo synthesis of 5-LO, able to induce a switch from the synthesis of proinflammatory LTB(4) to the synthesis of the proresolving LXA(4).
Gene_expression (synthesis) of LTB
3) Confidence 0.52 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321784 Disease Relevance 0.56 Pain Relevance 0.27
These results indicated that ZLJ-6 potently inhibited 5-lipoxygenase and cyclooxygenase, and blocked the production of LTB(4), TXB(2) and PGE(2).
Gene_expression (production) of LTB
4) Confidence 0.22 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19243697 Disease Relevance 0.51 Pain Relevance 0.26
Triene prostaglandins were not detected in the exudate, however, significant levels of LTB5 were present.
Gene_expression (present) of LTB5
5) Confidence 0.11 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3006690 Disease Relevance 0.60 Pain Relevance 0.26

General Comments

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