INT334776

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.67
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Angptl4) extracellular space (Angptl4) extracellular region (Angptl4)
proteinaceous extracellular matrix (Angptl4)
Anatomy Link Frequency
F19 6
liver 3
gut 2
adipose tissue 1
Angptl4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 80 96.48 Very High Very High Very High
agonist 8 96.40 Very High Very High Very High
anesthesia 8 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dyslipidemia /

Combined Dyslipidemia

8 99.56 Very High Very High Very High
Obesity 96 99.44 Very High Very High Very High
Sprains And Strains 24 98.96 Very High Very High Very High
Diabetes Mellitus 8 98.88 Very High Very High Very High
Weight Gain 24 82.44 Quite High
Colon Cancer 8 81.44 Quite High
Metabolic Syndrome 8 80.36 Quite High
Targeted Disruption 8 70.40 Quite High
Weight Loss 16 68.28 Quite High
Disease 8 67.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that ANGPTL4 expression can be induced by an array of probiotic strains including F19.
Positive_regulation (induced) of Gene_expression (expression) of ANGPTL4 in F19 associated with sprains and strains
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.42 Pain Relevance 0
were downregulated by siRNA in HT29 cells induction of ANGPTL4 expression by F19 was markedly reduced (Figure 4B), revealing a partial nuclear receptor dependency for this gut microbiota mediated effect.
Positive_regulation (induction) of Gene_expression (expression) of ANGPTL4 in gut
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0 Pain Relevance 0
Conditioned media from F19 co-cultured with HCT116 cells was, on the contrary, sufficient, even when heat-inactivated, to increase ANGPTL4 expression.
Positive_regulation (increase) of Gene_expression (expression) of ANGPTL4 in F19
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.21 Pain Relevance 0
In contrast, the anaerobic commensal B. thetaiotaomicron, is unable to induce ANGPTL4 which is in line with the reported inability of whole flora to increase ANGPTL4 expression [6].
Neg (unable) Positive_regulation (increase) of Gene_expression (expression) of ANGPTL4
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.40 Pain Relevance 0
Circulating ANGPTL4 levels were upregulated in the F19 supplemented group (Figure 1D).
Positive_regulation (upregulated) of Gene_expression (levels) of ANGPTL4 in F19
5) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.30 Pain Relevance 0.10
In contrast, the anaerobic commensal B. thetaiotaomicron, is unable to induce ANGPTL4 which is in line with the reported inability of whole flora to increase ANGPTL4 expression [6].
Neg (unable) Positive_regulation (increase) of Gene_expression (expression) of ANGPTL4
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.41 Pain Relevance 0
ANGPTL4 has been reported to be highly expressed in liver and adipose tissue [5], and plasma levels of the protein decrease on a chronic high-fat diet [4].
Positive_regulation (highly) of Gene_expression (expressed) of ANGPTL4 in liver associated with obesity
7) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.87 Pain Relevance 0.05
ANGPTL4 has been reported to be highly expressed in liver and adipose tissue [5], and plasma levels of the protein decrease on a chronic high-fat diet [4].
Positive_regulation (highly) of in adipose tissue Gene_expression (expressed) of ANGPTL4 in liver associated with obesity
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.87 Pain Relevance 0.05

General Comments

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