INT334853

Context Info Confidence 0.22 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.29

extracellular space (C4b) extracellular region (C4b)

Anatomy Link Frequency nucleus 1 NFAT 1 C4b (Mus musculus)

Pain Link Frequency Relevance Heat unmyelinated 4 81.56 nav1.8 2 66.28 c fibre 2 65.72 Central nervous system 2 54.88 Peripheral nervous system 4 50.96 Demyelination 12 48.28 dorsal root ganglion 6 5.00

Disease Link Frequency Relevance Heat Demyelinating Disease 14 48.28 Ganglion Cysts 6 5.00 Neuropathic Pain 4 5.00 Adhesions 4 5.00 Injury 2 5.00 Targeted Disruption 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Lack of calcineurin B prevents neuregulin-induced dephosphorylation and activation of NFAT c3 and c4.

Phosphorylation (dephosphorylation) of c4 in NFAT

1) Confidence 0.22 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.03

This activates the phosphatase calcineurin, which dephosphorylates nuclear factor of activated T cells (NFAT) c3 and c4, resulting in translocation to the nucleus.

Phosphorylation (dephosphorylates) of c4 in nucleus

2) Confidence 0.22 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.26

General Comments

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