INT334861

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4b) extracellular region (C4b)
Anatomy Link Frequency
NFAT 4
C4b (Mus musculus)
Mpz (Mus musculus)
Pain Link Frequency Relevance Heat
unmyelinated 4 60.40 Quite High
Peripheral nervous system 4 53.04 Quite High
nav1.8 2 45.12 Quite Low
c fibre 2 44.56 Quite Low
Central nervous system 2 33.72 Quite Low
Demyelination 12 27.12 Quite Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 14 27.12 Quite Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, NFAT c4 complexes with Sox-10, a transcription factor required for myelination [17], to activate the promoter and myelin-specific enhancer of the Krox-20 gene, which globally regulates peripheral myelination [11,18-20], and also with the promoter of the myelin protein zero (P0) gene, all of which underline the involvement of NFAT proteins in myelination.
Positive_regulation (activate) of c4 Binding (complexes) of P0 in NFAT
1) Confidence 0.13 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.06
Furthermore, NFAT c4 complexes with Sox-10, a transcription factor required for myelination [17], to activate the promoter and myelin-specific enhancer of the Krox-20 gene, which globally regulates peripheral myelination [11,18-20], and also with the promoter of the myelin protein zero (P0) gene, all of which underline the involvement of NFAT proteins in myelination.
Positive_regulation (activate) of c4 Binding (complexes) of myelin protein zero in NFAT
2) Confidence 0.10 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.06

General Comments

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