INT334879

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.63
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP1, IL1B) signal transduction (CASP1, IL1B) aging (IL1B)
intracellular (CASP1) cell-cell signaling (IL1B) cytoplasm (CASP1)
CASP1 (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
anakinra 4 91.04 High High
antagonist 3 86.80 High High
Arthritis 3 76.16 Quite High
spinal inflammation 1 75.36 Quite High
psoriasis 1 74.40 Quite High
Crohn's disease 3 70.16 Quite High
Inflammation 4 41.80 Quite Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 6 96.16 Very High Very High Very High
Fever 8 95.76 Very High Very High Very High
Disease 19 95.16 Very High Very High Very High
Syndrome 19 92.20 High High
Immune System Diseases 3 80.04 Quite High
Seronegative Spondarthritis 1 76.16 Quite High
Low Back Pain 1 75.36 Quite High
Psoriasis 1 74.40 Quite High
Amyloidosis 1 63.12 Quite High
Rare Diseases 1 58.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro and murine studies have shown that the B30.2 domain of pyrin interacts directly with caspase-1 to modulate IL-1?
caspase-1 Regulation (modulate) of IL-1
1) Confidence 0.03 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948378 Disease Relevance 1.63 Pain Relevance 0.31

General Comments

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