INT334926

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 10.11
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hypothalamus 1
pituitary 1
bowel 1
MEHMO (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 21 99.50 Very High Very High Very High
Pain 7 98.56 Very High Very High Very High
corticosteroid 35 98.40 Very High Very High Very High
Opioid 21 92.76 High High
Lasting pain 14 86.84 High High
Oxycodone 7 85.48 High High
Morphine 7 84.16 Quite High
depression 14 83.84 Quite High
methadone 7 83.76 Quite High
alcohol 14 80.36 Quite High
Disease Link Frequency Relevance Heat
Hypogonadotropic Hypogonadism 511 100.00 Very High Very High Very High
Inflammatory Bowel Disease 7 99.78 Very High Very High Very High
Immunotherapy Of Cancer 7 99.70 Very High Very High Very High
Pulmonary Disease 35 99.14 Very High Very High Very High
Cancer 70 99.12 Very High Very High Very High
Pain 21 98.56 Very High Very High Very High
Asthma 7 98.24 Very High Very High Very High
INFLAMMATION 21 97.68 Very High Very High Very High
Lipodystrophy 7 97.64 Very High Very High Very High
Hypophysis Disease 7 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, patients being treated with glucocorticoids for such chronic conditions as rheumatoid and osteoarthritic inflammation, skin inflammations, asthma, chronic obstructive pulmonary disease (COPD) and inflammatory bowel disease are at an increased risk of hypogonadism.
Positive_regulation (increased) of hypogonadism in bowel associated with asthma, pulmonary disease, inflammation, hypogonadotropic hypogonadism and osteoarthritis
1) Confidence 0.02 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 1.37 Pain Relevance 0.50
The cause of this hypogonadism is probably as a result of a number of factors, including lipodystrophy induced by highly active retroviral medications; testicular atrophy caused by opportunistic infection; disruption of the HPG axis resulting from malnutrition; and the results of medications such as the antimycotic ketoconazole, which inhibits steroid biosynthesis (17).



Positive_regulation (cause) of hypogonadism associated with appetite loss, opportunistic infections, reprotox - general 3, hypogonadotropic hypogonadism and lipodystrophy
2) Confidence 0.02 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 1.71 Pain Relevance 0.13
The mechanism for OPIAD is thought to involve suppression of GnRH release by the hypothalamus, thereby inducing secondary hypogonadism (17,70).


Positive_regulation (inducing) of hypogonadism in hypothalamus associated with hypogonadotropic hypogonadism
3) Confidence 0.02 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 1.83 Pain Relevance 0.91
Apart from the effects of testicular cancers, which may have a direct impact on testosterone secretion, the prolonged radiation treatment, chemotherapy using antimitotic drugs or corticosteroids or pain treatment medications characteristic of cancer treatment are likely to induce hypogonadism (17).
Spec (likely) Positive_regulation (induce) of hypogonadism associated with pain, corticosteroid, hypogonadotropic hypogonadism, testicular cancer and immunotherapy of cancer
4) Confidence 0.02 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 1.69 Pain Relevance 0.79
Secondary hypogonadism can be caused by a number of conditions (Table 3) including hypothalamic and pituitary disorders or lesions, hyperprolactinemia and Kallmann syndrome (which causes a GnRH deficiency) (16).
Positive_regulation (caused) of hypogonadism in pituitary associated with galactorrhea, hypophysis disease, hypogonadotropic hypogonadism and kallmann syndrome
5) Confidence 0.02 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 1.98 Pain Relevance 0.04
A consistent feature of these studies is that hypogonadism increases with age.
Positive_regulation (increases) of hypogonadism associated with hypogonadotropic hypogonadism
6) Confidence 0.02 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 0.32 Pain Relevance 0
As hypogonadism increases with age and is significantly associated with various comorbidities such as obesity, type 2 diabetes, hypertension, osteoporosis and metabolic syndrome, the physician is increasingly likely to have to treat hypogonadism in the clinic.
Positive_regulation (increases) of hypogonadism associated with diabetes mellitus, hypogonadotropic hypogonadism, hypertension, osteoporosis and metabolic syndrome
7) Confidence 0.02 Published 2010 Journal International Journal of Clinical Practice Section Abstract Doc Link PMC2948422 Disease Relevance 1.21 Pain Relevance 0

General Comments

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