INT33495

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Context Info
Confidence 0.23
First Reported 1986
Last Reported 1986
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ahsg) extracellular region (Ahsg) protein complex assembly (Ahsg)
protein complex (Ahsg)
Anatomy Link Frequency
smooth muscle 1
Ahsg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 3 99.46 Very High Very High Very High
Dopamine 3 99.24 Very High Very High Very High
noradrenaline 6 98.04 Very High Very High Very High
Potency 3 95.08 Very High Very High Very High
agonist 3 86.96 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relative order of potency for the agonists at postjunctional alpha 1-adrenoreceptors mediating contraction of smooth muscle in epididymal segments of the vas deferens was: (-)-adrenaline greater than or equal to (-)-noradrenaline greater than phenylephrine greater than clonidine greater than or equal to (+)-adrenaline greater than or equal to methoxamine greater than or equal to (+)-noradrenaline greater than or equal to metaraminol greater than or equal to dopamine greater than or equal to (-)-isoprenaline greater than or equal to xylazine; (+)-isoprenaline was inactive. (+)-Noradrenaline, the stereoisomers of adrenaline and isoprenaline, dopamine, clonidine, xylazine and metaraminol displayed alpha 2-selectivity whereas phenylephrine and methoxamine displayed alpha 1-adrenoreceptor selectivity. (-)-Noradrenaline possessed a similar potency at both alpha 1- and alpha 2-adrenoreceptors thus making it non-selective by the criteria used in this study.
Regulation (displayed) of alpha 2-selectivity in smooth muscle associated with dopamine, noradrenaline, agonist, clonidine and potency
1) Confidence 0.23 Published 1986 Journal J Auton Pharmacol Section Abstract Doc Link 3007522 Disease Relevance 0 Pain Relevance 0.86

General Comments

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