INT33496

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Context Info
Confidence 0.46
First Reported 1985
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 6.05
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
follicle 8
ovary 4
gonadal 2
pituitary 2
urine 2
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 77 98.84 Very High Very High Very High
Clonidine 7 98.64 Very High Very High Very High
agonist 120 95.36 Very High Very High Very High
narcan 4 94.56 High High
opiate 2 91.00 High High
noradrenaline 1 84.80 Quite High
antagonist 103 83.84 Quite High
Spinal cord 1 54.32 Quite High
Analgesic 1 44.60 Quite Low
Pain 31 42.96 Quite Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 143 99.20 Very High Very High Very High
Fibromyalgia 77 98.84 Very High Very High Very High
Recurrence 15 98.64 Very High Very High Very High
Sleep Disorders 4 97.44 Very High Very High Very High
Endometriosis (extended) 79 97.36 Very High Very High Very High
Obesity 48 97.08 Very High Very High Very High
Pressure Volume 2 Under Development 2 96.64 Very High Very High Very High
Anovulation 48 94.92 High High
Endocrine Disease 1 93.96 High High
Aging 27 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The costs per cycle of r FSH and HP FSH were compared in 2 trials and in both the cost per cycle were higher for rFSH even though in both trials a lower FSH dose could be used.31
Positive_regulation (used.31) of Gene_expression (dose) of FSH
1) Confidence 0.46 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.07 Pain Relevance 0
By transfecting a Chinese hamster ovary cell line with FSH genes recombinant FSH could be stably produced and was introduced in clinical practice in 1992.9 Recombinant FSH is homogenous and free of contamination by proteins.
Positive_regulation (transfecting) of Gene_expression (transfecting) of FSH in ovary
2) Confidence 0.46 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.17 Pain Relevance 0
Recombinant DNA engineering technology allows for the production of human FSH in Chinese hamster ovary cells [4].
Positive_regulation (allows) of Gene_expression (production) of FSH in ovary
3) Confidence 0.45 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC270000 Disease Relevance 0.62 Pain Relevance 0
FSH is derived from urine or is produced as recombinant FSH.
Positive_regulation (derived) of Gene_expression (produced) of FSH in urine
4) Confidence 0.42 Published 2010 Journal International Journal of Women's Health Section Abstract Doc Link PMC2971716 Disease Relevance 0.27 Pain Relevance 0
RESULTS: One week after surgery, a GnRH-stimulation test disclosed normal basal and stimulated FSH levels and low levels of inhibin B and estradiol.
Positive_regulation (stimulated) of Gene_expression (levels) of FSH
5) Confidence 0.38 Published 2007 Journal Horm. Res. Section Body Doc Link 16974107 Disease Relevance 0.14 Pain Relevance 0
Follitropin alpha has a specific activity of 10,000 IU/mg which is similar to the urinary highly purified urofollitropin but is 100 times higher than that of other urinary derived FSH products.8,33 Follitropin alpha has been shown to induce follicular growth on its own without the addition of LH in most cases.34,35 However, the role of LH for optimal follicular development has been recently described – especially in profoundly LH deficient women with hypogonadotrophic hypogonadism.36,37 Although a minimum level of serum LH is required for optimum growth, excess LH can cause follicular growth arrest and prevent growing follicles from reaching the late antral stage.38,39 Follitropin alpha administration has been associated with a significant increase in serum levels of estradiol level, inhibin A and inhibin B.40,41 Significant increases in follicular levels of insulin and growth hormone have been detected in follitropin stimulated women.20

Pharmacokinetics

Positive_regulation (derived) of Gene_expression (products.8,33) of FSH in follicles associated with reprotox - general 2
6) Confidence 0.34 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.09 Pain Relevance 0
How does even brief exposure to high estrogen levels through tamoxifen or FSH-letrozole stimulation affect the risk of breast cancer recurrence?
Positive_regulation (stimulation) of Gene_expression (exposure) of FSH associated with recurrence and reprotox - general 1
7) Confidence 0.33 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397531 Disease Relevance 0.79 Pain Relevance 0.03
Mukherjee et al. [13] suggested that an elevated day 3 FSH: LH ratio >3.6, in the presence of a normal day 3 FSH is predictive of a poor response to ovarian stimulation.
Positive_regulation (response) of Gene_expression (predictive) of FSH
8) Confidence 0.32 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0.14 Pain Relevance 0.14
Mukherjee et al. [13] suggested that an elevated day 3 FSH: LH ratio >3.6, in the presence of a normal day 3 FSH is predictive of a poor response to ovarian stimulation.
Positive_regulation (response) of Gene_expression (predictive) of FSH
9) Confidence 0.32 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0.14 Pain Relevance 0.13
Levels of other anterior pituitary hormones (prolactin, luteinizing hormone and follicle stimulating hormone) and of arginine vasopressin were unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (Levels) of follicle stimulating hormone in follicle
10) Confidence 0.28 Published 1985 Journal J Hypertens Suppl Section Abstract Doc Link 3007707 Disease Relevance 0.63 Pain Relevance 0.90
Testosterone was found to augment follicular FSH receptor expression in primates suggesting that androgens promote follicular growth and estrogen biosynthesis indirectly by amplifying FSH effects [411,412].
Positive_regulation (augment) of Gene_expression (expression) of FSH receptor
11) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.05 Pain Relevance 0
In addition, androgen accumulation in the follicle may stimulate insulin-like growth factor I (IGF-I), along with other endocrine and paracrine factors, which may synergize with FSH to promote folliculogenesis [413-416].
Spec (may) Positive_regulation (stimulate) of Gene_expression (synergize) of FSH in follicle
12) Confidence 0.20 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.13 Pain Relevance 0
GnRH seems to be a more physiologic agent for increasing the pituitary’s production of FSH and LH, especially when it is administered in a pulsatile fashion in programmable, portable minipumps.
Positive_regulation (increasing) of Gene_expression (production) of FSH in pituitary
13) Confidence 0.19 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721319 Disease Relevance 0.35 Pain Relevance 0
They found that fibromyalgia patients had significantly lower estrogen levels despite elevated FSH levels.
Positive_regulation (elevated) of Gene_expression (levels) of FSH associated with fibrositis
14) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416440 Disease Relevance 1.65 Pain Relevance 0.43
Levels of both FSH and LH rise steadily during the period of follicle depletion during the peri-menopausal period, but the detailed dynamics involved are incompletely understood.
Positive_regulation (rise) of Gene_expression (Levels) of FSH in follicle associated with endometriosis (extended)
15) Confidence 0.12 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764709 Disease Relevance 0.54 Pain Relevance 0
Table 2 also shows that serum levels of FSH and LH were slightly but not significantly increased at follow-up (p = 0.07, for both hormones).


Neg (not) Positive_regulation (increased) of Gene_expression (levels) of FSH
16) Confidence 0.07 Published 2006 Journal BMC Urol Section Body Doc Link PMC1444919 Disease Relevance 0.18 Pain Relevance 0.03
In humans, administration of leuprorelin initially increases circulating levels of LH and FSH, leading to a transient increase in levels of the gonadal steroids.
Positive_regulation (increases) of Gene_expression (levels) of FSH in gonadal
17) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504071 Disease Relevance 0.07 Pain Relevance 0

General Comments

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