INT334963

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Cnga1) cytoplasm (Cnga1)
Cnga1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 7 75.12 Quite High
Pyramidal cell 30 45.92 Quite Low
Neuronal excitability 9 40.04 Quite Low
anticonvulsant 1 38.64 Quite Low
agonist 6 23.92 Low Low
Action potential 14 9.40 Low Low
antagonist 7 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 11 5.00 Very Low Very Low Very Low
Parkinson's Disease 3 5.00 Very Low Very Low Very Low
Dyskinesias 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the application of NO, there was also a decrease in input resistance during this long hyperpolarizing current injection (Rinput; Fig. 4H and J), as expected from increased HCN channel activation.
Positive_regulation (increased) of Positive_regulation (activation) of HCN
1) Confidence 0.26 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.08
There is a cyclic nucleotide-binding domain (CNDB) on the C-terminal of each HCN channel subunit, and the binding of cAMP directly facilitates activation of HCN channels [20].
Positive_regulation (facilitates) of Positive_regulation (activation) of HCN
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948503 Disease Relevance 0 Pain Relevance 0

General Comments

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