INT334975

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.74
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 20
Disease Relevance 7.12
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fgf15)
Anatomy Link Frequency
liver 5
embryonic brain 1
fat 1
embryonic stages 1
spinal cord 1
Fgf15 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 320 99.32 Very High Very High Very High
Spinal cord 20 97.32 Very High Very High Very High
Pain 20 88.84 High High
agonist 20 58.48 Quite High
sodium channel 20 39.36 Quite Low
cytokine 20 5.00 Very Low Very Low Very Low
Eae 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 740 99.78 Very High Very High Very High
Heart Defects 20 98.88 Very High Very High Very High
Pancreatic Cancer 20 98.16 Very High Very High Very High
Hypophosphatemia 80 97.60 Very High Very High Very High
Extrahepatic Cholestasis 20 97.00 Very High Very High Very High
Disease 120 96.24 Very High Very High Very High
Rickets 360 95.12 Very High Very High Very High
Cancer 100 92.96 High High
B-cell Acute Lymphoblastic Leukemia 20 90.76 High High
Abscess 20 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mice, the expression of Fgf15 exhibits a regionally restricted pattern in the developing nervous system, suggesting that Fgf15 has roles in regulating cell division and patterning within specific regions of the embryonic brain, spinal cord, and sensory organs (McWhirter et al. 1997).
Gene_expression (expression) of Fgf15 in spinal cord associated with spinal cord
1) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.14 Pain Relevance 0.05
Fgf15 and Fgfr4 are expressed in the intestine and liver, respectively.
Gene_expression (expressed) of Fgf15 in intestine
2) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.32 Pain Relevance 0.22
Later, Fgf15/19, Fgf21, and Fgf23 were generated by two large-scale genome duplication events during the evolution of early vertebrates
Gene_expression (generated) of Fgf15
3) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0 Pain Relevance 0
(Fgf15) Intestinal Fgf15 expression is regulated by bile acid produced in the liver.
Gene_expression (expression) of Fgf15 in liver associated with bile
4) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.22 Pain Relevance 0.25
The ligand-bound FXR forms a heterodimer with RXRs and induces the expression of Fgf15.
Gene_expression (expression) of Fgf15
5) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.20 Pain Relevance 0.24
(Fgf15) Intestinal Fgf15 expression is regulated by bile acid produced in the liver.
Gene_expression (expression) of Fgf15 in liver associated with bile
6) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.22 Pain Relevance 0.25
Transgenic mice over-expressing human Fgf19 showed a significant and specific reduction in fat mass and an increase in energy expenditure, indicating potential roles for Fgf19 in energy metabolism (Tomlinson et al. 2002).
Gene_expression (expressing) of Fgf19 in fat associated with targeted disruption
7) Confidence 0.64 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.25 Pain Relevance 0.05
Fgf15 was originally identified as a downstream target of the chimeric homoedomain oncoprotein E2A-Pbx1 in mice (McWhirter et al. 1997).
Gene_expression (target) of Fgf15
8) Confidence 0.64 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.17 Pain Relevance 0
Heart defects were observed in the embryonic stages, indicating that Fgf15 is required for proper morphogenesis of the cardiac outflow tract during embryonic development (TableĀ 1) (Vincentz et al. 2005).
Gene_expression (required) of Fgf15 in embryonic stages associated with heart defects
9) Confidence 0.64 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.33 Pain Relevance 0.04
Although Fgf15/19, Fgf21, and Fgf23 are not very similar (?
Gene_expression (/) of Fgf15
10) Confidence 0.64 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.53 Pain Relevance 0.09
Later, Fgf19, Fgf21, and Fgf23 were generated from Fgf19-like by two large-scale genome duplication events (Itoh and Ornitz 2004; Itoh and Ornitz 2008).
Gene_expression (generated) of Fgf19
11) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0 Pain Relevance 0
Although not expressed in the normal liver, Fgf19 is abundantly expressed in the liver of cholestatic patients.
Gene_expression (expressed) of Fgf19 in liver
12) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.63 Pain Relevance 0.05
Intestinal Fgf15 expression is regulated by bile acid produced in the mouse liver.
Gene_expression (expression) of Fgf15 in liver associated with bile
13) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.36 Pain Relevance 0.16
Later, Fgf15/19, Fgf21, and Fgf23 were generated from the ancestral gene by genome duplication events.
Gene_expression (generated) of Fgf15
14) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2948652 Disease Relevance 0.08 Pain Relevance 0
The ligand-bound FXR forms a heterodimer with retinoid X receptors (RXRs) and induces the expression of Fgf15.
Gene_expression (expression) of Fgf15
15) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.22 Pain Relevance 0.20
Fgf15/19 and Fgf23 require ?
Gene_expression (/) of Fgf15
16) Confidence 0.56 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2948652 Disease Relevance 0.31 Pain Relevance 0.04
Identification of the Fgf19/21/23 gene subfamily
Gene_expression (/) of Fgf19
17) Confidence 0.56 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.55 Pain Relevance 0.09
In mice, the expression of Fgf15 exhibits a regionally restricted pattern in the developing nervous system, suggesting that Fgf15 has roles in regulating cell division and patterning within specific regions of the embryonic brain, spinal cord, and sensory organs (McWhirter et al. 1997).
Gene_expression (expression) of Fgf15 in embryonic brain associated with spinal cord
18) Confidence 0.25 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.14 Pain Relevance 0.05
In mice, the expression of Fgf15 exhibits a regionally restricted pattern in the developing nervous system, suggesting that Fgf15 has roles in regulating cell division and patterning within specific regions of the embryonic brain, spinal cord, and sensory organs (McWhirter et al. 1997).
Gene_expression (expression) of Fgf15 in sensory organs associated with spinal cord
19) Confidence 0.25 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.14 Pain Relevance 0.05
Fgf15 and Fgfr4 are expressed in the intestine and liver, respectively.
Gene_expression (expressed) of Fgf15 in liver
20) Confidence 0.25 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.32 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox