INT334987

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Context Info
Confidence 0.66
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.32
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fgf15)
Anatomy Link Frequency
bile 1
Fgf15 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 96 99.62 Very High Very High Very High
Spinal cord 6 43.04 Quite Low
Pain 6 39.00 Quite Low
agonist 6 32.88 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
sodium channel 6 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 222 99.96 Very High Very High Very High
Metabolic Disorder 48 99.84 Very High Very High Very High
Disease 36 99.48 Very High Very High Very High
Extrahepatic Cholestasis 6 99.28 Very High Very High Very High
Cancer 30 97.96 Very High Very High Very High
Pancreatic Cancer 6 97.80 Very High Very High Very High
Inborn Genetic Diseases 18 97.56 Very High Very High Very High
Toxicity 6 95.96 Very High Very High Very High
Obesity 102 92.84 High High
Fatty Liver 30 90.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ancestral gene, Fgf19-like, was generated from Fgf4-like by local gene duplication early in vertebrate evolution.
Positive_regulation (generated) of Fgf19-like
1) Confidence 0.66 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0 Pain Relevance 0
In addition, serum Fgf19 or Fgf21 levels are significantly increased by metabolic disorders.
Positive_regulation (increased) of Fgf19 associated with metabolic disorder
2) Confidence 0.66 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2948652 Disease Relevance 0.49 Pain Relevance 0.04
Fgf15/19-like, an ancestral gene of the hormone-like Fgf subfamily, was generated from Fgf4-like by local gene duplication early in vertebrate evolution.
Positive_regulation (generated) of Fgf15
3) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0 Pain Relevance 0
Serum Fgf19 levels are also significantly increased in patients on chronic hemodialysis (TableĀ 2) (Reiche et al. 2010).
Positive_regulation (increased) of Fgf19
4) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.95 Pain Relevance 0.05
Serum Fgf19 levels are markedly elevated in patients with extrahepatic cholestasis caused by a pancreatic tumor.
Positive_regulation (elevated) of Fgf19 associated with extrahepatic cholestasis and pancreatic cancer
5) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.48 Pain Relevance 0.04
Fecal bile acid excretion is increased in Fgf15 knockout mice (Inagaki et al. 2005).
Positive_regulation (increased) of Fgf15 in bile associated with targeted disruption and bile
6) Confidence 0.41 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.40 Pain Relevance 0.18

General Comments

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