INT334997

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.56
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf23) extracellular space (Fgf23) extracellular region (Fgf23)
Fgf23 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 80 40.40 Quite Low
Pain 5 34.08 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
sodium channel 5 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Calcification 30 98.00 Very High Very High Very High
Targeted Disruption 185 95.92 Very High Very High Very High
Cancer 25 95.60 Very High Very High Very High
Metabolic Disorder 40 92.24 High High
Rickets 90 90.56 High High
Disease 30 88.64 High High
Hypophosphatemia 20 86.64 High High
Renal Failure 5 74.88 Quite High
Abscess 5 34.92 Quite Low
Pain 5 34.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss-of-function mutation of Galnt3 impairs secretion of intact Fgf23, leading to decreased serum Fgf23 levels and hyperphosphatemia (Ichikawa et al. 2009).
Localization (secretion) of Fgf23
1) Confidence 0.72 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.14 Pain Relevance 0
These results provide in vivo evidence that Galnt3 plays an essential role in the proper secretion of Fgf23.
Localization (secretion) of Fgf23
2) Confidence 0.72 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.13 Pain Relevance 0
The O-glycosylation prevents proteolytic processing of Fgf23 and allows the secretion of an intact Fgf23 (Kato et al. 2006; Frishberg et al. 2007).
Localization (secretion) of Fgf23
3) Confidence 0.72 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.22 Pain Relevance 0
Later, Fgf15/19, Fgf21, and Fgf23 were generated from the ancestral gene by genome duplication events.
Localization (generated) of Fgf23
4) Confidence 0.58 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2948652 Disease Relevance 0.08 Pain Relevance 0
Later, Fgf19, Fgf21, and Fgf23 were generated from Fgf19-like by two large-scale genome duplication events (Itoh and Ornitz 2004; Itoh and Ornitz 2008).
Localization (generated) of Fgf23
5) Confidence 0.58 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0 Pain Relevance 0

General Comments

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