INT334998

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Context Info
Confidence 0.66
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.80
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fgf21)
Anatomy Link Frequency
liver 2
fat 1
Fgf21 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 80 88.84 High High
Pain 5 57.20 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
sodium channel 5 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 85 100.00 Very High Very High Very High
Metabolic Disorder 40 99.84 Very High Very High Very High
Diabetes Mellitus 10 99.28 Very High Very High Very High
Fatty Liver 25 98.00 Very High Very High Very High
Targeted Disruption 185 97.76 Very High Very High Very High
Cancer 25 97.60 Very High Very High Very High
Inborn Genetic Diseases 15 97.20 Very High Very High Very High
Insulin Resistance 5 93.80 High High
Syndrome 5 87.12 High High
Hypertrophy 5 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, serum Fgf19 or Fgf21 levels are significantly increased by metabolic disorders.
Positive_regulation (increased) of Fgf21 associated with metabolic disorder
1) Confidence 0.66 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2948652 Disease Relevance 0.49 Pain Relevance 0.04
These results indicate that Fgf21 regulates lipolysis in adipocytes in response to the metabolic state but is not required for ketogenesis or triglyceride clearance in the liver (TableĀ 1).
Neg (not) Positive_regulation (required) of Fgf21 in liver associated with obesity
2) Confidence 0.48 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.15 Pain Relevance 0
These results suggest that Fgf21 acts as a metabolic regulator of lipolysis in the white adipose tissue and is required for ketogenesis and triglyceride clearance in the liver.
Positive_regulation (required) of Fgf21 in liver associated with obesity
3) Confidence 0.48 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.10 Pain Relevance 0
Serum Fgf21 levels are increased in patients with type 2 diabetes and obesity (TableĀ 2) (Zhang et al 2008; Chen et al 2008; Mraz et al 2009).
Positive_regulation (increased) of Fgf21 associated with diabetes mellitus and obesity
4) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.24 Pain Relevance 0.04
Fgf21 was also identified as a gene inducible by fasting or a high-fat, low-carbohydrate ketogenic diet in mice (Inagaki et al. 2007; Badman et al. 2007)

Fgf23

Positive_regulation (inducible) of Fgf21 in fat
5) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.83 Pain Relevance 0.06

General Comments

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