INT335

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Context Info
Confidence 0.36
First Reported 1978
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 6.16
Pain Relevance 6.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra1a) aging (Adra1a) plasma membrane (Adra1a)
response to stress (Adra1a) signal transducer activity (Adra1a)
Anatomy Link Frequency
smooth muscle 1
aorta 1
cerebral cortex 1
muscle 1
lymphocytes 1
Adra1a (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 16 100.00 Very High Very High Very High
Endep 7 100.00 Very High Very High Very High
tricyclic antidepressant 2 100.00 Very High Very High Very High
antagonist 16 99.96 Very High Very High Very High
narcan 17 99.64 Very High Very High Very High
cerebral cortex 6 99.44 Very High Very High Very High
Migraine 6 98.76 Very High Very High Very High
Opioid 2 98.72 Very High Very High Very High
Catecholamine 3 98.48 Very High Very High Very High
addiction 1 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Benign Prostatic Hypertrophy 14 99.74 Very High Very High Very High
Lower Urinary Tract Symptoms 14 99.66 Very High Very High Very High
Overactive Bladder 4 99.56 Very High Very High Very High
Headache 6 98.76 Very High Very High Very High
Hypersensitivity 2 98.28 Very High Very High Very High
Intracranial Vasospasm 1 96.84 Very High Very High Very High
Shock 1 95.52 Very High Very High Very High
Aggression 1 95.04 Very High Very High Very High
Volume Depletion And Dehydration 1 95.04 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 3 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several ligands bind to specific sites in brain membranes with alpha-adrenergic receptor properties.
alpha-adrenergic receptor Binding (bind) of in brain
1) Confidence 0.36 Published 1978 Journal Brain Res. Section Abstract Doc Link 31963 Disease Relevance 0 Pain Relevance 0.37
In vitro characterization of alpha-adrenergic receptor in rabbit detrusor muscle.
alpha-adrenergic receptor Binding (characterization) of in muscle associated with overactive bladder
2) Confidence 0.36 Published 1987 Journal Jpn. J. Pharmacol. Section Title Doc Link 2888917 Disease Relevance 0.28 Pain Relevance 0.06
Loss of catecholamine histofluorescence, increased sensitivity to norepinephrine, and changes in alpha1 receptor binding have led to the proposal that denervation hypersensitivity may play a role in cerebrovascular spasm.
alpha1 receptor Binding (binding) of associated with intracranial vasospasm, catecholamine and hypersensitivity
3) Confidence 0.36 Published 1986 Journal J. Neurosurg. Section Abstract Doc Link 3944639 Disease Relevance 0.35 Pain Relevance 0.20
In this study, we aimed to reveal the interaction between the tricyclic antidepressant amitriptyline and a1-adrenoceptor antagonist prazosin in mice by using an analgesiometric device hot-plate.
a1-adrenoceptor Binding (interaction) of associated with antagonist, endep and tricyclic antidepressant
4) Confidence 0.35 Published 2005 Journal Agri Section Abstract Doc Link 15791502 Disease Relevance 0 Pain Relevance 0.75
Although the precise mechanism is not known, myocardial alpha-adrenergic receptor blockage with verapamil and nifedipine remains a possible explanation for increased myocardial NE release.
alpha-adrenergic receptor Binding (blockage) of
5) Confidence 0.32 Published 1985 Journal Am. Heart J. Section Abstract Doc Link 3966338 Disease Relevance 0.60 Pain Relevance 0.58
Alpha 1-adrenergic blockers: do they have a place in the prophylaxis of migraine?
1-adrenergic Binding (have) of associated with migraine
6) Confidence 0.29 Published 1997 Journal Headache Section Title Doc Link 9074296 Disease Relevance 0.54 Pain Relevance 0.53
MIR given repeatedly (but not acutely) increased the binding (Bmax ) of [3H]prazosin to alpha1-adrenergic receptors in cerebral cortex, however, the ability of the alpha1-adrenoceptor agonist phenylephrine to compete for the these sites was not significantly changed.
alpha1-adrenergic Binding (binding) of in cerebral cortex associated with agonist and cerebral cortex
7) Confidence 0.26 Published 2002 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11939713 Disease Relevance 0.19 Pain Relevance 0.36
No binding of the alpha 1 adrenoceptor antagonist prazosin was observed and the binding properties of beta adrenergic receptors (assayed with 3H-labelled dihydroalprenolol), were similar to those described for normal lymphocytes.
alpha 1 adrenoceptor Neg (No) Binding (binding) of in lymphocytes associated with antagonist
8) Confidence 0.23 Published 1991 Journal Int. J. Cancer Section Abstract Doc Link 1652566 Disease Relevance 0.16 Pain Relevance 0.24
The alpha1-adrenoceptor subtypes involved in the control of vascular tone are currently being evaluated, and the profile of interaction with the various alpha1-adrenoceptor subtypes may play a key role in the efficacy of cardiovascular drugs such as carvedilol.
alpha1-adrenoceptor Binding (interaction) of
9) Confidence 0.16 Published 1997 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15989605 Disease Relevance 0.58 Pain Relevance 0.41
Alpha adrenergic receptor subtype associated with receptor binding, Ca++ influx, Ca++ release and contractile events in the rabbit aorta.
Alpha adrenergic receptor Binding (associated) of in aorta
10) Confidence 0.15 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6312022 Disease Relevance 0 Pain Relevance 0.30
Vascular interactions among alpha adrenergic receptor agents, naloxone, and selected opioids were investigated.
alpha adrenergic receptor Binding (interactions) of associated with narcan and opioid
11) Confidence 0.09 Published 1990 Journal Circ. Shock Section Abstract Doc Link 1972664 Disease Relevance 0.10 Pain Relevance 0.61
Piperazinylimidazo[1,2-a]pyrazines with selective affinity for in vitro alpha-adrenergic receptor subtypes.
alpha-adrenergic receptor Binding (affinity) of
12) Confidence 0.07 Published 1983 Journal J. Med. Chem. Section Title Doc Link 6298426 Disease Relevance 0.10 Pain Relevance 0.19
In summary, in rabbit gastric circular smooth muscle: (1) VIP, adenosine, and norepinephrine induce relaxation; (2) VIP loses efficacy with age; (3) there is a beta-adrenergic receptor mediating relaxation in the newborn which persists, and (4) an alpha-adrenergic receptor mediating contraction emerges early in postnatal life.
alpha-adrenergic receptor Binding (emerges) of in smooth muscle associated with adenocard
13) Confidence 0.04 Published 1993 Journal Biol. Neonate Section Abstract Doc Link 8297941 Disease Relevance 0 Pain Relevance 0.32
Differential interactions of clonidine and methoxamine with the postsynaptic alpha-adrenoceptor of rabbit main pulmonary artery.
alpha-adrenoceptor Binding (interactions) of in pulmonary artery associated with clonidine
14) Confidence 0.04 Published 1983 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 6188897 Disease Relevance 0.08 Pain Relevance 0.81
Without any exception it applies to all three PDE 5 inhibitors that they are absolutely contraindicated in patients taking nitrate- or molsidomine-containing medications and that they may interact in particular with non-uroselective alpha-adrenoceptor blockers.
alpha-adrenoceptor Binding (interact) of
15) Confidence 0.01 Published 2004 Journal Urologe A Section Abstract Doc Link 15197447 Disease Relevance 0.36 Pain Relevance 0.09
Current medical treatment of LUTS/BPH consists of monotherapy with alpha1-adrenoceptor (AR) antagonists, 5alpha-reductase inhibitors (RIs) or a combination of these.
alpha1-adrenoceptor Binding (monotherapy) of associated with benign prostatic hypertrophy, antagonist and lower urinary tract symptoms
16) Confidence 0.00 Published 2005 Journal BJU Int. Section Abstract Doc Link 15871731 Disease Relevance 2.83 Pain Relevance 0.19

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