INT335021

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.49
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf23) mitochondrion (Cyp27b1) extracellular space (Fgf23)
oxidoreductase activity (Cyp27b1) aging (Cyp27b1) extracellular region (Fgf23)
Anatomy Link Frequency
kidney 2
Fgf23 (Mus musculus)
Cyp27b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 64 80.72 Quite High
Eae 4 60.44 Quite High
agonist 4 56.64 Quite High
cytokine 4 20.12 Low Low
Spinal cord 4 5.00 Very Low Very Low Very Low
sodium channel 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hematological Disease 8 81.72 Quite High
Disease 24 80.32 Quite High
Obesity 68 76.96 Quite High
Extrahepatic Cholestasis 4 74.56 Quite High
Pancreatic Cancer 4 71.60 Quite High
Hypothermia 12 67.00 Quite High
Targeted Disruption 148 62.24 Quite High
Ketosis 4 56.44 Quite High
Hypoglycemia 4 56.08 Quite High
Toxicity 4 53.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased Fgf23 suppresses the expression of Cyp27b1 and induces the expression of Cyp24 by activating the ?
Fgf23 Negative_regulation (suppresses) of Gene_expression (expression) of Cyp27b1
1) Confidence 0.53 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.19 Pain Relevance 0.13
The suppression of Cyp27b1 expression and induction of Cyp24 expression by Fgf23 result in decreased levels of active vitamin D in serum.
Fgf23 Negative_regulation (suppression) of Gene_expression (expression) of Cyp27b1
2) Confidence 0.39 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.34 Pain Relevance 0.03
In addition, Fgf23 also suppresses the expression of Cyp27b1 (1?
Fgf23 Negative_regulation (suppresses) of Gene_expression (expression) of Cyp27b1
3) Confidence 0.39 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.73 Pain Relevance 0.03
The Fgf23 suppresses the expression of Cyp27b1 and induces the expression of Cyp24 in the kidney (Shimada et al 2004).
Fgf23 Negative_regulation (suppresses) of Gene_expression (expression) of Cyp27b1 in kidney
4) Confidence 0.39 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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