INT33516

Context Info Confidence 0.49 First Reported 1985 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 2.50 Pain Relevance 0.93

plasma membrane (TSHR) cell-cell signaling (TSHR) signal transducer activity (TSHR)

Anatomy Link Frequency plasma 2 thyroid 1 TSHR (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 6 99.36 depression 3 94.24 Opioid 4 92.48 opioid receptor 2 85.84 antagonist 1 84.56 narcan 1 83.68 Pain 2 77.44 dexamethasone 2 77.20 Inflammation 13 76.16 palliative 1 39.20

Disease Link Frequency Relevance Heat Hoarseness 2 98.72 Body Weight 1 98.56 Thyroid Disease 25 98.12 Colon Cancer 3 96.64 Depression 3 94.24 Schizophrenia 1 93.44 Personality Disorder 1 92.36 Disease 11 89.64 Pressure And Volume Under Development 3 89.60 Graves' Ophthalmopathy 31 89.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The serum thyrotropin (TSH) was markedly elevated to 118.14 microIU/mL and serum free thyroxine (fT4) level was markedly suppressed to 0.34 ng/dL.

Positive_regulation (elevated) of The serum thyrotropin

1) Confidence 0.49 Published 2006 Journal Endocr. J. Section Abstract Doc Link 16714841 Disease Relevance 1.12 Pain Relevance 0.08

Although the evidence provides strong overall support for a role of the TSH-r in the pathogenesis of TAO, whether TSH-r antibodies are really linked to ophthalmopathy in all cases of TAO remains unclear.

Positive_regulation (role) of TSH-r

2) Confidence 0.46 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.00 Pain Relevance 0.07

Intravenous infusion (5.5 microgram/kg/min for 30 min) of dermorphin (D) significantly increased plasma levels of prolactin (PRL), growth hormone (GH), thyrotropin (TSH) and renin activity (PRA), but decreased plasma levels of cortisol.

Positive_regulation (increased) of thyrotropin in plasma

3) Confidence 0.07 Published 1985 Journal Peptides Section Abstract Doc Link 3008118 Disease Relevance 0 Pain Relevance 0.31

Plasma cortisol, prolactin (PRL), growth hormone (GH), and thyroid stimulating hormone (TSH) responses to intravenous morphine (0.1 mg/kg body weight) were investigated in five healthy women and 22 female psychiatric inpatients (eight with major depression, 12 with schizophrenia and two with personality disorders) during a 120 min period.

Spec (investigated) Positive_regulation (responses) of stimulating hormone in Plasma associated with body weight, depression, personality disorder, schizophrenia and morphine

4) Confidence 0.01 Published 1987 Journal Psychoneuroendocrinology Section Abstract Doc Link 3588810 Disease Relevance 0.38 Pain Relevance 0.48

Serial measurements of plasma GH, IGF-1 and thyroid stimulating hormone (TSH) levels were made at baseline and following intravenous administration of 1 mcg/kg GHRH.

Positive_regulation (measurements) of stimulating hormone in thyroid

5) Confidence 0.00 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 11041314 Disease Relevance 0 Pain Relevance 0

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