INT33516

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Context Info
Confidence 0.49
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.50
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TSHR) cell-cell signaling (TSHR) signal transducer activity (TSHR)
Anatomy Link Frequency
plasma 2
thyroid 1
TSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 6 99.36 Very High Very High Very High
depression 3 94.24 High High
Opioid 4 92.48 High High
opioid receptor 2 85.84 High High
antagonist 1 84.56 Quite High
narcan 1 83.68 Quite High
Pain 2 77.44 Quite High
dexamethasone 2 77.20 Quite High
Inflammation 13 76.16 Quite High
palliative 1 39.20 Quite Low
Disease Link Frequency Relevance Heat
Hoarseness 2 98.72 Very High Very High Very High
Body Weight 1 98.56 Very High Very High Very High
Thyroid Disease 25 98.12 Very High Very High Very High
Colon Cancer 3 96.64 Very High Very High Very High
Depression 3 94.24 High High
Schizophrenia 1 93.44 High High
Personality Disorder 1 92.36 High High
Disease 11 89.64 High High
Pressure And Volume Under Development 3 89.60 High High
Graves' Ophthalmopathy 31 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The serum thyrotropin (TSH) was markedly elevated to 118.14 microIU/mL and serum free thyroxine (fT4) level was markedly suppressed to 0.34 ng/dL.
Positive_regulation (elevated) of The serum thyrotropin
1) Confidence 0.49 Published 2006 Journal Endocr. J. Section Abstract Doc Link 16714841 Disease Relevance 1.12 Pain Relevance 0.08
Although the evidence provides strong overall support for a role of the TSH-r in the pathogenesis of TAO, whether TSH-r antibodies are really linked to ophthalmopathy in all cases of TAO remains unclear.
Positive_regulation (role) of TSH-r
2) Confidence 0.46 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.00 Pain Relevance 0.07
Intravenous infusion (5.5 microgram/kg/min for 30 min) of dermorphin (D) significantly increased plasma levels of prolactin (PRL), growth hormone (GH), thyrotropin (TSH) and renin activity (PRA), but decreased plasma levels of cortisol.
Positive_regulation (increased) of thyrotropin in plasma
3) Confidence 0.07 Published 1985 Journal Peptides Section Abstract Doc Link 3008118 Disease Relevance 0 Pain Relevance 0.31
Plasma cortisol, prolactin (PRL), growth hormone (GH), and thyroid stimulating hormone (TSH) responses to intravenous morphine (0.1 mg/kg body weight) were investigated in five healthy women and 22 female psychiatric inpatients (eight with major depression, 12 with schizophrenia and two with personality disorders) during a 120 min period.
Spec (investigated) Positive_regulation (responses) of stimulating hormone in Plasma associated with body weight, depression, personality disorder, schizophrenia and morphine
4) Confidence 0.01 Published 1987 Journal Psychoneuroendocrinology Section Abstract Doc Link 3588810 Disease Relevance 0.38 Pain Relevance 0.48
Serial measurements of plasma GH, IGF-1 and thyroid stimulating hormone (TSH) levels were made at baseline and following intravenous administration of 1 mcg/kg GHRH.
Positive_regulation (measurements) of stimulating hormone in thyroid
5) Confidence 0.00 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 11041314 Disease Relevance 0 Pain Relevance 0

General Comments

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