INT33517

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Context Info
Confidence 0.71
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 14.65
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TSHR) cell-cell signaling (TSHR) signal transducer activity (TSHR)
Anatomy Link Frequency
thyroid 7
adipocyte 3
eye 2
fat 2
plasma 1
TSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 1 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
Inflammation 144 99.32 Very High Very High Very High
agonist 14 99.18 Very High Very High Very High
Opioid 5 91.80 High High
flare ups 4 91.44 High High
opioid receptor 2 85.84 High High
Pain 15 85.00 Quite High
antagonist 1 84.56 Quite High
narcan 1 83.68 Quite High
Disease Link Frequency Relevance Heat
Thyroiditis 363 99.62 Very High Very High Very High
INFLAMMATION 99 99.32 Very High Very High Very High
Disease 188 99.28 Very High Very High Very High
Thyroid Disease 296 99.24 Very High Very High Very High
Obesity 31 99.20 Very High Very High Very High
Graves' Ophthalmopathy 353 99.10 Very High Very High Very High
Exophthalmos 58 99.04 Very High Very High Very High
Hyperthyroidism 45 98.00 Very High Very High Very High
Panic Disorder 2 97.60 Very High Very High Very High
Autoimmune Disease 242 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One well studied candidate in this immune reaction is the thyroid-stimulating hormone receptor (TSH-r), expressed in the orbital fibroblast and pre adipocyte.
Gene_expression (expressed) of thyroid-stimulating hormone receptor in adipocyte
1) Confidence 0.71 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2874268 Disease Relevance 0.80 Pain Relevance 0.04
Certainly, the TSH-r is a logical candidate antigen as it is expressed in orbital preadipocytes and fibroblasts as well as the thyroid gland.12,13 Its expression in other tissues such as fat and connective tissue may also help to explain the development of pretibial myxedema and thyroid acropachy in some patients with Graves’ disease.14,15 Although not shown in all reports, some studies have shown that TSH-r antibody levels correlate directly with clinical features of GO7 further implicating its role in the pathogenesis of TAO.
Gene_expression (expressed) of TSH-r in thyroid associated with hypothyroidism, graves' ophthalmopathy and disease
2) Confidence 0.71 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.86 Pain Relevance 0.09
Furthermore, the TSH-r is also expressed in fibroblasts and adipocytes at sites such as the abdominal wall which are unaffected in Graves’ disease patients.16 In patients with Hashimoto’s thyroiditis, eye changes occur in the presumed absence of TSH-r antibody production.
Gene_expression (expressed) of TSH-r in eye associated with thyroiditis, graves' ophthalmopathy, obesity and disease
3) Confidence 0.71 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.13 Pain Relevance 0.06
Furthermore, the TSH-r is also expressed in fibroblasts and adipocytes at sites such as the abdominal wall which are unaffected in Graves’ disease patients.16 In patients with Hashimoto’s thyroiditis, eye changes occur in the presumed absence of TSH-r antibody production.
Gene_expression (production) of TSH-r in eye associated with thyroiditis, graves' ophthalmopathy, obesity and disease
4) Confidence 0.71 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.06 Pain Relevance 0.03
One well studied candidate in this immune reaction is the thyroid-stimulating hormone receptor (TSH-r), expressed in the orbital fibroblast and pre adipocyte.
Gene_expression (expressed) of TSH-r in adipocyte
5) Confidence 0.62 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2874268 Disease Relevance 0.79 Pain Relevance 0.04
There have been reports of the development of TSH-r positive Graves’ hyperthyroidism and ophthalmopathy following SAT.37,38 However, Amato et al39 recently reported the case of a Caucasian male who developed euthyroid Graves’ disease after proven SAT in the absence of TSH-r antibodies but with detectable eye muscle antibodies.
Gene_expression (antibodies) of TSH-r in eye muscle associated with thyroiditis, thyroid disease, graves' ophthalmopathy and disease
6) Confidence 0.61 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 2.28 Pain Relevance 0.04
TSH-r hypothesis
Gene_expression (hypothesis) of TSH-r
7) Confidence 0.61 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.47 Pain Relevance 0.16
The orbital antigen, Fp, was also found to be significantly up-regulated, 1.4-fold, while genes encoding collagen XIII, FOXP1/G2s, thyroglobulin, thyroid peroxidise and the TSH-r, were not differentially expressed.48
Gene_expression (encoding) of TSH-r in thyroid
8) Confidence 0.61 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.18 Pain Relevance 0
The orbital antigen, Fp, was also found to be significantly up-regulated, 1.4-fold, while genes encoding collagen XIII, FOXP1/G2s, thyroglobulin, thyroid peroxidise and the TSH-r, were not differentially expressed.48
Neg (not) Gene_expression (expressed.48) of TSH-r in thyroid
9) Confidence 0.61 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.13 Pain Relevance 0
The general consensus is that TAO is likely to reflect an autoimmune reaction during which sensitized T-cells and autoantibodies are directed against a thyroid and orbital tissue shared antigen such as the thyroid-stimulating hormone receptor (TSH-r) which is expressed in the thyroid, OCT and fat and, possibly, the extraocular muscle fiber (Box 1).9
Gene_expression (expressed) of thyroid-stimulating hormone receptor in fat
10) Confidence 0.55 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.55 Pain Relevance 0
The general consensus is that TAO is likely to reflect an autoimmune reaction during which sensitized T-cells and autoantibodies are directed against a thyroid and orbital tissue shared antigen such as the thyroid-stimulating hormone receptor (TSH-r) which is expressed in the thyroid, OCT and fat and, possibly, the extraocular muscle fiber (Box 1).9
Gene_expression (expressed) of TSH-r in fat
11) Confidence 0.55 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.49 Pain Relevance 0
Apart from assessment of thyroid stimulating hormone (TSH), echocardiography and exercise testing, no other technical investigations were carried out.
Gene_expression (assessment) of thyroid stimulating hormone in thyroid
12) Confidence 0.26 Published 2004 Journal GMS Psycho-Social Medicine Section Body Doc Link PMC2736487 Disease Relevance 0.85 Pain Relevance 0.04
These results suggest that TSHr expression in orbital fibroblasts may be linked to adipogenesis, and that the activation of the PPAR-?
Gene_expression (expression) of TSHr in fibroblasts
13) Confidence 0.24 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1876204 Disease Relevance 0.52 Pain Relevance 0.11
Recent studies have suggested a link between the expression of the thyroid stimulating hormone receptor (TSHr) and adipogenesis in the orbital tissues of patients with TAO [6,7].
Gene_expression (expression) of TSHr in thyroid
14) Confidence 0.24 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1876204 Disease Relevance 0.69 Pain Relevance 0.14
by its agonist, TZD, was shown to stimulate functional TSHr expression, and also to induce the recruitment and differentiation of orbital fibroblasts into mature lipid-laden adipocytes [7-9].
Gene_expression (expression) of TSHr in adipocytes associated with obesity and agonist
15) Confidence 0.24 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1876204 Disease Relevance 0.59 Pain Relevance 0.13
Recent studies have suggested a link between the expression of the thyroid stimulating hormone receptor (TSHr) and adipogenesis in the orbital tissues of patients with TAO [6,7].
Gene_expression (expression) of stimulating hormone receptor in thyroid
16) Confidence 0.21 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1876204 Disease Relevance 0.69 Pain Relevance 0.14
Lithium has been found to interfere with the production of thyroid hormones including the inhibition of the thyroid stimulating hormone (TSH)-responsive adenylate cyclase and PKC in thyroid cells [22-24].
Gene_expression (production) of thyroid stimulating hormone in thyroid
17) Confidence 0.18 Published 2008 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2531078 Disease Relevance 0.54 Pain Relevance 0
Intravenous infusion (5.5 microgram/kg/min for 30 min) of dermorphin (D) significantly increased plasma levels of prolactin (PRL), growth hormone (GH), thyrotropin (TSH) and renin activity (PRA), but decreased plasma levels of cortisol.
Gene_expression (levels) of thyrotropin in plasma
18) Confidence 0.08 Published 1985 Journal Peptides Section Abstract Doc Link 3008118 Disease Relevance 0 Pain Relevance 0.31
These include thyrotropin receptor (Santini et al. 2003), iodine uptake by the sodium iodide transporter (Schröder van der Elst et al. 2003), type 1 5?
Gene_expression (include) of thyrotropin receptor
19) Confidence 0.08 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2866686 Disease Relevance 0.07 Pain Relevance 0.04
NE cells produce specific proteins, such as neuron specific enolase (NSE), chromograninA (CgA), bombesin, serotonin, somatostatin, a thyroid-stimulating-like peptide, parathyroid hormone-related peptides, and calcitonin which are secreted into the blood stream.
Gene_expression (produce) of thyroid-stimulating-like peptide in parathyroid associated with somatostatin and serotonin
20) Confidence 0.07 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3018395 Disease Relevance 0.96 Pain Relevance 0.10

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