INT33518

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Context Info
Confidence 0.39
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.14
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
plasma 2
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 1 99.90 Very High Very High Very High
antagonist 1 99.72 Very High Very High Very High
opioid receptor 2 99.50 Very High Very High Very High
Opioid 4 80.76 Quite High
Somatostatin 5 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Electroencephalography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acromegaly 7 75.16 Quite High
Disease 3 62.48 Quite High
Adenoma 14 5.00 Very Low Very Low Very Low
Thyroid Disease 13 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Prolactinoma 3 5.00 Very Low Very Low Very Low
Obesity 3 5.00 Very Low Very Low Very Low
Thyroid Hormone Resistance Syndrome 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with the opioid receptor antagonist naloxone (N) suppressed the PRL and TSH response to D, blunted the D-induced GH and PRA increase, and completely prevented the D-induced plasma cortisol decrease, but enhanced plasma cortisol and ACTH levels.
Negative_regulation (suppressed) of Regulation (response) of PRL in plasma associated with antagonist, narcan and opioid receptor
1) Confidence 0.39 Published 1985 Journal Peptides Section Abstract Doc Link 3008118 Disease Relevance 0 Pain Relevance 0.41
The regularity of PRL patterns in patients was diminished compared with controls, as defined by higher ApEn ratios in patients (0.788 ± 0.074, mean ± SD) than controls (0.461 ± 0.131, P < 0.001).Fig. 5Serum prolactin concentration profiles of 5 patients with a thyrotropinoma.
Negative_regulation (diminished) of Regulation (regularity) of PRL
2) Confidence 0.31 Published 2008 Journal Pituitary Section Body Doc Link PMC2712623 Disease Relevance 0.14 Pain Relevance 0

General Comments

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