INT335215

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.98
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ERBB3) extracellular space (ERBB3) extracellular region (ERBB3)
oxidoreductase activity (RDH5) plasma membrane (ERBB3) nucleus (ERBB3)
RDH5 (Homo sapiens)
ERBB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 26 100.00 Very High Very High Very High
Breast Cancer 38 98.22 Very High Very High Very High
Apoptosis 47 97.04 Very High Very High Very High
Cancer 13 69.40 Quite High
Targeted Disruption 1 12.08 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Advanced Or Metastatic Breast Cancer 5 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Headache 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another study demonstrated that RA can induce differentiation of cultured breast tumor cells, and this was again associated with reduction in cell surface HER2 [35]. atRA and 9-cis-RA caused decreases in HER2 and HER3, and inhibited SKBR3 cell growth with cell cycle arrest and induction of apoptosis [36], and the retinoids downregulated HER4 in T47D cells [37]; atRA also downregulated HER2 and HER3 in MCF cells [38]. 4-HPR was reported in another study to downregulate both HER2 and the epidermal growth factor receptor (EGFR, HER1) [39].
9-cis-RA Positive_regulation (caused) of Negative_regulation (decreases) of HER3 associated with breast cancer, rheumatoid arthritis and apoptosis
1) Confidence 0.03 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.98 Pain Relevance 0

General Comments

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