INT335240

Context Info Confidence 0.28 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.81 Pain Relevance 0

extracellular region (CD8A, PMEL) plasma membrane (CD8A, PMEL) endosome (PMEL) Golgi apparatus (PMEL) endoplasmic reticulum (PMEL)

Anatomy Link Frequency T-cells 2 CD8A (Homo sapiens) PMEL (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 2 11.68 corticosteroid 2 5.00 cytokine 2 5.00 Pain 2 5.00 imagery 2 5.00 Potency 2 5.00 cva 2 5.00

Disease Link Frequency Relevance Heat Melanoma 54 80.72 Cancer 58 79.96 Disease 8 72.04 Hypopigmentation 28 57.20 INFLAMMATION 2 11.68 Acquired Immune Deficiency Syndrome Or Hiv Infection 24 5.00 Cytomegalovirus Infection 16 5.00 Anaemia 2 5.00 Metastasis 2 5.00 Toxicity 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

With the MHC-Dextramer assay, which can detect the T-cell receptor capable of binding specifically to the gp100-in4 peptide presented on a particular MHC molecule, an increase in frequency of T-cells with the gp-100-specific T-cell receptor was observed in all patients after the initiation of vaccination.

T-cell receptor Binding (binding) of gp100-in4 in T-cells

1) Confidence 0.28 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.34 Pain Relevance 0

With the MHC-Dextramer assay, which can detect the T-cell receptor capable of binding specifically to the gp100-in4 peptide presented on a particular MHC molecule, an increase in frequency of T-cells with the gp-100-specific T-cell receptor was observed in all patients after the initiation of vaccination.

T-cell receptor Binding (binding) of gp100-in4 in T-cells

2) Confidence 0.19 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.47 Pain Relevance 0

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