INT335289

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) aging (TIMP1) extracellular region (TIMP1)
nucleus (IRF6) DNA binding (IRF6) cytoplasm (IRF6)
IRF6 (Homo sapiens)
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 36 84.32 Quite High
metalloproteinase 6 50.00 Quite Low
Inflammation 14 5.00 Very Low Very Low Very Low
sodium channel 10 5.00 Very Low Very Low Very Low
anticonvulsant 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Antiepileptic agent 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 2 92.00 High High
Convulsion 4 66.56 Quite High
Gingival Overgrowth 20 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Pathologic Processes 4 5.00 Very Low Very Low Very Low
Wound Healing 4 5.00 Very Low Very Low Very Low
Fibrosis 2 5.00 Very Low Very Low Very Low
Periodontal Disease 2 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, LPS markedly induced supernatant MMP-1, MMP-3, MMP-9, TIMP-1 but not MMP-2 levels in our 6 independent cultures after a 24 hour exposure (Fig. 1A-D).
LPS Neg (not) Positive_regulation (induced) of Gene_expression (levels) of TIMP-1
1) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.07 Pain Relevance 0
Previous studies have demonstrated that LPS from this organism is capable of inducing MMP and TIMP production [28-30] and our preliminary studies determined that this concentration of LPS was capable of significantly inducing TNF-?
LPS Positive_regulation (inducing) of Gene_expression (production) of TIMP
2) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.09 Pain Relevance 0.04

General Comments

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