INT335299

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.21 Pain Relevance 0.19

cytosol (IRF6) aging (TIMP1) extracellular region (TIMP1) nucleus (IRF6) DNA binding (IRF6) cytoplasm (IRF6)

IRF6 (Homo sapiens) TIMP1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 54 94.04 fibrosis 3 77.68 metalloproteinase 9 50.00 sodium channel 15 26.16 tetrodotoxin 3 19.16 Inflammation 21 5.00 anticonvulsant 6 5.00 Inflammatory response 3 5.00 Antiepileptic agent 3 5.00 agonist 3 5.00

Disease Link Frequency Relevance Heat Fibrosis 3 77.68 Convulsion 6 69.76 Gingival Overgrowth 30 5.00 INFLAMMATION 24 5.00 Pathologic Processes 6 5.00 Wound Healing 6 5.00 Periodontal Disease 3 5.00 Sprains And Strains 3 5.00 Hyperplasia 3 5.00 Injury 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As expected, LPS markedly induced supernatant MMP-1, MMP-3, MMP-9, TIMP-1 but not MMP-2 levels in our 6 independent cultures after a 24 hour exposure (Fig. 1A-D).

LPS Neg (not) Positive_regulation (induced) of TIMP-1

1) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.07 Pain Relevance 0

Our results demonstrate that PHT as well as its metabolite, HPPH significantly blunt A. actinomycetemcomitans LPS-induced levels of MMP-1, MMP-3, MMP-9 and TIMP-1 in a dose-dependent manner and that a high concentration of PHT significantly decreases TNF-?

LPS Positive_regulation (induced) of TIMP-1

2) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.08 Pain Relevance 0.19

PHT and HPPH inhibit LPS-induced supernatant levels of MMP-1, MMP-3, MMP-9, and TIMP-1 in a dose dependent manner

LPS Positive_regulation (induced) of TIMP-1

3) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.07 Pain Relevance 0

General Comments

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