INT335299

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.21
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) aging (TIMP1) extracellular region (TIMP1)
nucleus (IRF6) DNA binding (IRF6) cytoplasm (IRF6)
IRF6 (Homo sapiens)
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 54 94.04 High High
fibrosis 3 77.68 Quite High
metalloproteinase 9 50.00 Quite Low
sodium channel 15 26.16 Quite Low
tetrodotoxin 3 19.16 Low Low
Inflammation 21 5.00 Very Low Very Low Very Low
anticonvulsant 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Antiepileptic agent 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 3 77.68 Quite High
Convulsion 6 69.76 Quite High
Gingival Overgrowth 30 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Pathologic Processes 6 5.00 Very Low Very Low Very Low
Wound Healing 6 5.00 Very Low Very Low Very Low
Periodontal Disease 3 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, LPS markedly induced supernatant MMP-1, MMP-3, MMP-9, TIMP-1 but not MMP-2 levels in our 6 independent cultures after a 24 hour exposure (Fig. 1A-D).
LPS Neg (not) Positive_regulation (induced) of TIMP-1
1) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.07 Pain Relevance 0
Our results demonstrate that PHT as well as its metabolite, HPPH significantly blunt A. actinomycetemcomitans LPS-induced levels of MMP-1, MMP-3, MMP-9 and TIMP-1 in a dose-dependent manner and that a high concentration of PHT significantly decreases TNF-?
LPS Positive_regulation (induced) of TIMP-1
2) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.08 Pain Relevance 0.19
PHT and HPPH inhibit LPS-induced supernatant levels of MMP-1, MMP-3, MMP-9, and TIMP-1 in a dose dependent manner
LPS Positive_regulation (induced) of TIMP-1
3) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox