INT3353

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Context Info
Confidence 0.75
First Reported 1978
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 16.05
Pain Relevance 8.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
macrophages 1
B35 1
chondrocytes 1
vertebral column 1
anterior 1
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 258 99.84 Very High Very High Very High
Inflammation 34 99.56 Very High Very High Very High
spondylitis 21 99.50 Very High Very High Very High
Arthritis 99 99.40 Very High Very High Very High
cINOD 22 98.42 Very High Very High Very High
backache 6 97.40 Very High Very High Very High
psoriasis 31 93.64 High High
fibrosis 6 90.92 High High
rheumatoid arthritis 24 75.00 Quite High
Osteoarthritis 37 57.96 Quite High
Disease Link Frequency Relevance Heat
Disease 78 100.00 Very High Very High Very High
Sacroiliitis 3 99.88 Very High Very High Very High
Low Back Pain 164 99.84 Very High Very High Very High
Targeted Disruption 6 99.72 Very High Very High Very High
INFLAMMATION 30 99.56 Very High Very High Very High
Seronegative Spondarthritis 187 99.50 Very High Very High Very High
Arthritis 46 99.40 Very High Very High Very High
Necrosis 4 99.16 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 83 99.12 Very High Very High Very High
Uveitis 23 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Citrullination-dependent differential presentation of a self-peptide by HLA-B27 subtypes.
Localization (presentation) of HLA-B27 associated with inflammation
1) Confidence 0.75 Published 2008 Journal J. Biol. Chem. Section Title Doc Link 18650441 Disease Relevance 0.25 Pain Relevance 0.21
Because of the involvement of tumor necrosis factor (TNF) in cartilage damage and the localization of the TNF genes in the proximity of the HLA-B locus, we investigated the association between AS and TNF alleles.
Localization (localization) of HLA-B in cartilage associated with spinal inflammation, necrosis and cancer
2) Confidence 0.73 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 1672816 Disease Relevance 0.88 Pain Relevance 0.61
Similarly, in macrophages from HLA-B27-expressing disease-prone transgenic rats, HLA-B27 dimer-like structures are readily detected after stimulation with interferon (IFN)-?
Localization (disease) of HLA-B27-expressing in macrophages associated with targeted disruption and disease
3) Confidence 0.72 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.29 Pain Relevance 0.09
Therefore, the HLA-B35 allele was implicated in susceptibility to Kawasaki disease and the HLA-B75 allele in susceptibility to Kawasaki disease without CC.
Localization (implicated) of HLA-B35 allele in B35 associated with mucocutaneous lymph node syndrome
4) Confidence 0.72 Published 2007 Journal Pediatr Cardiol Section Body Doc Link PMC2267487 Disease Relevance 0.89 Pain Relevance 0
CONCLUSION: The polymorphism of human TAP does not affect the translocated repertoire of HLA-B27 ligands and is therefore unlikely to play a decisive role in the development of HLA-B27-associated disease.


Localization (translocated) of HLA-B27
5) Confidence 0.70 Published 1996 Journal Arthritis Rheum. Section Body Doc Link 8912512 Disease Relevance 0 Pain Relevance 0
METHODS: TAP translocation of a panel of HLA-B27-binding peptides was measured with a labeled reporter peptide containing an N-linked glycosylation acceptor site in streptolysin O-permeabilized cells with different TAP alleles.
Localization (translocation) of HLA-B27-binding
6) Confidence 0.70 Published 1996 Journal Arthritis Rheum. Section Body Doc Link 8912512 Disease Relevance 0 Pain Relevance 0
Among the 111 healthy controls, 80% presented HLA-B 2,705, followed by HLA-B 2,702 in 10%, HLA-B 2,703 in 6%, HLA-B 2,707 in 3% and HLA-B 2,713 in 1%.
Localization (presented) of HLA-B
7) Confidence 0.69 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 17717670 Disease Relevance 1.03 Pain Relevance 0.55
Two black male patients with aortic insufficiency were later found to have mild, asymptomatic ankylosing spondylitis, evident from roentgenograms and from the presence of HLA-B27 antigen.
Localization (presence) of HLA-B27 associated with spinal inflammation
8) Confidence 0.68 Published 1978 Journal JAMA Section Abstract Doc Link 712985 Disease Relevance 0.36 Pain Relevance 0.36
The diagnosis of ankylosing spondylitis was based on the presence of inflammatory low back pain responsive to nonsteroidal anti-inflammatory drugs, syndesmophytes at the lumbar and cervical spine, bilateral sacroiliitis, and presence of the HLA-B27 antigen.
Localization (presence) of HLA-B27 in spine associated with low back pain, spinal inflammation, sacroiliitis, inflammation, cinod and backache
9) Confidence 0.68 Published 2002 Journal Joint Bone Spine Section Abstract Doc Link 12477237 Disease Relevance 1.31 Pain Relevance 0.87
Certain etiological factors and anatomical locations suggest an analogy between the two affections, with conditions predisposing to fibrous changes, one result of which being the presence of HLA-B27 antigen.
Localization (presence) of HLA-B27
10) Confidence 0.68 Published 1981 Journal Ann Med Interne (Paris) Section Abstract Doc Link 7294587 Disease Relevance 0.33 Pain Relevance 0.25
[An HLA-B27 negative case of ankylosing spondylitis with acute iridocyclitis].
Localization (case) of HLA-B27 associated with iridocyclitis and spinal inflammation
11) Confidence 0.68 Published 1992 Journal Nippon Ganka Gakkai Zasshi Section Title Doc Link 1558026 Disease Relevance 0.79 Pain Relevance 0.44
The circulating immune complex levels in the serum of the patients were also determined for correlation with the presence of HLA-B27 antigen.
Localization (presence) of HLA-B27
12) Confidence 0.64 Published 1982 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 7035395 Disease Relevance 0.89 Pain Relevance 0.24
There was no significant association between demographic, clinical, biological, or radiological characteristics of the patients on the one hand, and the presence of the HLA-B27 allele on the other.
Localization (presence) of HLA-B27 allele
13) Confidence 0.59 Published 1997 Journal Scand. J. Rheumatol. Section Abstract Doc Link 9310106 Disease Relevance 0.74 Pain Relevance 0.19
In addition to their classical antigen-presenting role, it has been described that HLA-B27 are recognised by members of the KIR and leukocyte immunoglobulin-like receptor (ILT) families in both human and animal models.
Localization (recognised) of HLA-B27 in leukocyte
14) Confidence 0.58 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779409 Disease Relevance 0.43 Pain Relevance 0.29
Secondly, psoriatic spondylitis has been related to the presence of HLA-B27 in several reports worldwide (including the present study) in which this antigen might also be associated with some clinical aspects of this entity [12].
Localization (presence) of HLA-B27 associated with seronegative spondarthritis and spondylitis
15) Confidence 0.40 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794531 Disease Relevance 1.31 Pain Relevance 0.66
To explain the strong association between HLA-B27 and ankylosing spondylitis, we suggest that the release of beta(2)-microglobulin (beta(2)m) from a subpopulation of cell surface-expressed HLA-B27 molecules leads to beta(2)m-deposition within synovia and to the initiation of an inflammatory process, which culminates in destructive spondyloarthropathy.
Localization (release) of HLA-B27 associated with spinal inflammation and inflammation
16) Confidence 0.36 Published 2003 Journal Trends Immunol. Section Abstract Doc Link 12547503 Disease Relevance 0.35 Pain Relevance 0.22
Male sex, younger age at symptom onset, and hip involvement were associated with radiographic changes; but HLA-B27, peripheral arthritis, and extraarticular disease status (uveitis, psoriasis, and inflammatory bowel disease) were not.
Localization (disease) of HLA-B27 in bowel
17) Confidence 0.34 Published 2009 Journal J. Rheumatol. Section Body Doc Link 19447933 Disease Relevance 0 Pain Relevance 0
HLA-B27-restricted antigen presentation by human chondrocytes to CD8+ T cells: potential contribution to local immunopathologic processes in ankylosing spondylitis.
Localization (presentation) of HLA-B27 in chondrocytes associated with spinal inflammation
18) Confidence 0.29 Published 2009 Journal Arthritis Rheum. Section Title Doc Link 19479861 Disease Relevance 0.37 Pain Relevance 0.40
The tissue antigen HLA-B27 is found in 50% of Dutch acute anterior uveitis (AAU) patients.
Localization (found) of HLA-B27 in anterior associated with uveitis
19) Confidence 0.27 Published 1988 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 3262094 Disease Relevance 0.70 Pain Relevance 0.07
Four patients with peripheral arthritis had a rare HLA-B27 haplotype (HLA-B27, HLA-DR7) which was not found in the group with axial disease alone.
Neg (not) Localization (found) of HLA-B27 associated with disease and arthritis
20) Confidence 0.24 Published 1985 Journal J. Rheumatol. Section Abstract Doc Link 3876437 Disease Relevance 0.69 Pain Relevance 0.29

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