INT335307

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.69 Pain Relevance 0.29

aging (TIMP1) extracellular region (TIMP1) transmembrane transport (SLC15A4)

Anatomy Link Frequency macrophage 1 SLC15A4 (Homo sapiens) TIMP1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 36 99.78 Inflammation 14 92.16 metalloproteinase 6 50.00 anticonvulsant 4 6.40 sodium channel 10 5.00 tetrodotoxin 2 5.00 fibrosis 2 5.00 Inflammatory response 2 5.00 Antiepileptic agent 2 5.00 agonist 2 5.00

Disease Link Frequency Relevance Heat Injury 2 93.40 INFLAMMATION 16 92.16 Gingival Overgrowth 20 92.00 Pathologic Processes 4 70.96 Wound Healing 4 65.60 Convulsion 4 35.44 Fibrosis 2 5.00 Periodontal Disease 2 5.00 Sprains And Strains 2 5.00 Hyperplasia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The second tier of this analysis was aimed at determining whether PHT or HPPH have an effect on MMP, TIMP, TNF-?

PHT Spec (whether) Regulation (effect) of TIMP

1) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0

As tissue homeostasis requires the proper balance of metabolism and catabolism, it is possible that macrophage-derived cytokines, MMPs and TIMP levels are altered in response to PHT and HPPH.

PHT Regulation (altered) of TIMP in macrophage associated with cytokine

2) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.69 Pain Relevance 0.29

General Comments

This test has worked.