INT335312

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0

aging (TIMP1) extracellular region (TIMP1) transmembrane transport (SLC15A4)

SLC15A4 (Homo sapiens) TIMP1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 3 50.00 cytokine 18 22.20 Inflammation 7 5.00 sodium channel 5 5.00 anticonvulsant 2 5.00 tetrodotoxin 1 5.00 fibrosis 1 5.00 Inflammatory response 1 5.00 Antiepileptic agent 1 5.00 agonist 1 5.00

Disease Link Frequency Relevance Heat Convulsion 2 69.76 Gingival Overgrowth 10 5.00 INFLAMMATION 8 5.00 Pathologic Processes 2 5.00 Wound Healing 2 5.00 Fibrosis 1 5.00 Periodontal Disease 1 5.00 Sprains And Strains 1 5.00 Hyperplasia 1 5.00 Injury 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PHT and HPPH inhibit LPS-induced supernatant levels of MMP-1, MMP-3, MMP-9, and TIMP-1 in a dose dependent manner

PHT Negative_regulation (inhibit) of TIMP-1

1) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.