INT335321

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.02
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SLC15A4)
Anatomy Link Frequency
macrophages 4
fibroblast 2
SLC15A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 72 90.96 High High
Inflammation 28 90.00 High High
sodium channel 20 76.16 Quite High
Inflammatory response 4 66.64 Quite High
metalloproteinase 12 50.00 Quite Low
anticonvulsant 8 33.80 Quite Low
Calcium channel 4 28.64 Quite Low
Antiepileptic agent 4 25.40 Quite Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gingival Overgrowth 40 99.96 Very High Very High Very High
Pathologic Processes 8 98.36 Very High Very High Very High
Convulsion 8 96.24 Very High Very High Very High
Wound Healing 8 93.00 High High
INFLAMMATION 32 90.00 High High
Multiple Sclerosis 4 63.60 Quite High
Injury 4 60.96 Quite High
Fibrosis 4 5.00 Very Low Very Low Very Low
Periodontal Disease 4 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
How PHT and HPPH impact monocyte/macrophage-fibroblast interactions and MMP production requires further study.
Positive_regulation (requires) of Gene_expression (production) of PHT in fibroblast
1) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.19 Pain Relevance 0.12
We have demonstrated that the clinical presentation of PHT-induced gingival overgrowth is associated with a specific macrophage phenotype characterized by high expression levels of IL-1?
Positive_regulation (induced) of Gene_expression (presentation) of PHT in macrophage associated with gingival overgrowth
2) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.66 Pain Relevance 0.13
In this study, elevated levels of PHT in LPS-stimulated macrophages were associated with decreases in both MMP and TIMP levels.
Positive_regulation (elevated) of Gene_expression (levels) of PHT in macrophages
3) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.08 Pain Relevance 0
Thus, the concentrations used in our study represent therapeutic as well as elevated levels of PHT permitting the evaluation of dose on MMP and TIMP production.
Positive_regulation (elevated) of Gene_expression (levels) of PHT
4) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.10 Pain Relevance 0

General Comments

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