INT335327

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0.91 Pain Relevance 0.41

transmembrane transport (SLC15A4)

Anatomy Link Frequency macrophage 1 plasma 1 SLC15A4 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 72 90.20 fibrosis 4 82.80 Inflammation 28 75.56 agonist 4 73.84 metalloproteinase 12 50.00 sodium channel 20 22.32 tetrodotoxin 4 15.32 anticonvulsant 8 5.00 Inflammatory response 4 5.00 Antiepileptic agent 4 5.00

Disease Link Frequency Relevance Heat Gingival Overgrowth 40 94.92 Convulsion 8 83.92 Fibrosis 4 82.80 INFLAMMATION 32 75.56 Periodontal Disease 4 45.24 Pathologic Processes 8 44.04 Wound Healing 8 5.00 Sprains And Strains 4 5.00 Hyperplasia 4 5.00 Injury 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although PHT was detected in all of the GCF and plasma samples, the mean concentration of PHT was significantly greater in GCF compared to plasma (294.99 ± 430.15 ?

Positive_regulation (concentration) of PHT in plasma

1) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.45 Pain Relevance 0.18

Our results demonstrate that PHT as well as its metabolite, HPPH significantly blunt A. actinomycetemcomitans LPS-induced levels of MMP-1, MMP-3, MMP-9 and TIMP-1 in a dose-dependent manner and that a high concentration of PHT significantly decreases TNF-?

Positive_regulation (concentration) of PHT

2) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.08 Pain Relevance 0.16

In the present study, supernatant MMP levels did not demonstrate any significant differences in response to PHT and HPPH alone at either dose compared to untreated macrophage cultures although we noted a trend for higher levels of MMP-1 and MMP-3.

Positive_regulation (response) of PHT in macrophage

3) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.38 Pain Relevance 0.08

but not IL-6, is decreased in response to PHT

Positive_regulation (response) of PHT

4) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0

General Comments

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