INT335327

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.91
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SLC15A4)
Anatomy Link Frequency
macrophage 1
plasma 1
SLC15A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 72 90.20 High High
fibrosis 4 82.80 Quite High
Inflammation 28 75.56 Quite High
agonist 4 73.84 Quite High
metalloproteinase 12 50.00 Quite Low
sodium channel 20 22.32 Low Low
tetrodotoxin 4 15.32 Low Low
anticonvulsant 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Antiepileptic agent 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gingival Overgrowth 40 94.92 High High
Convulsion 8 83.92 Quite High
Fibrosis 4 82.80 Quite High
INFLAMMATION 32 75.56 Quite High
Periodontal Disease 4 45.24 Quite Low
Pathologic Processes 8 44.04 Quite Low
Wound Healing 8 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although PHT was detected in all of the GCF and plasma samples, the mean concentration of PHT was significantly greater in GCF compared to plasma (294.99 ± 430.15 ?
Positive_regulation (concentration) of PHT in plasma
1) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.45 Pain Relevance 0.18
Our results demonstrate that PHT as well as its metabolite, HPPH significantly blunt A. actinomycetemcomitans LPS-induced levels of MMP-1, MMP-3, MMP-9 and TIMP-1 in a dose-dependent manner and that a high concentration of PHT significantly decreases TNF-?
Positive_regulation (concentration) of PHT
2) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.08 Pain Relevance 0.16
In the present study, supernatant MMP levels did not demonstrate any significant differences in response to PHT and HPPH alone at either dose compared to untreated macrophage cultures although we noted a trend for higher levels of MMP-1 and MMP-3.
Positive_regulation (response) of PHT in macrophage
3) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.38 Pain Relevance 0.08
but not IL-6, is decreased in response to PHT
Positive_regulation (response) of PHT
4) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0

General Comments

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