INT335330

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.22
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SLC15A4)
SLC15A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 54 97.28 Very High Very High Very High
fibrosis 3 71.44 Quite High
metalloproteinase 9 60.88 Quite High
sodium channel 15 29.40 Quite Low
tetrodotoxin 3 22.40 Low Low
Inflammation 21 5.00 Very Low Very Low Very Low
anticonvulsant 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Antiepileptic agent 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gingival Overgrowth 30 91.08 High High
Fibrosis 3 71.44 Quite High
Convulsion 6 56.60 Quite High
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Pathologic Processes 6 5.00 Very Low Very Low Very Low
Wound Healing 6 5.00 Very Low Very Low Very Low
Periodontal Disease 3 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, this corresponds with our findings in that supernatant levels of TIMP-1 in samples treated with both LPS and high doses of PHT or HPPH were not significantly different relative to untreated controls (Fig. 2).
Localization (doses) of PHT
1) Confidence 0.04 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.09 Pain Relevance 0.03
Our results demonstrate that PHT as well as its metabolite, HPPH significantly blunt A. actinomycetemcomitans LPS-induced levels of MMP-1, MMP-3, MMP-9 and TIMP-1 in a dose-dependent manner and that a high concentration of PHT significantly decreases TNF-?
Localization (blunt) of PHT
2) Confidence 0.04 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.07 Pain Relevance 0.19
Compared to untreated control cultures, LPS significantly increased secretion of MMP-1 despite the presence of either PHT or HPPH at any dose.
Localization (presence) of PHT
3) Confidence 0.04 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.06 Pain Relevance 0

General Comments

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