INT335346

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.23 Pain Relevance 0.23

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos) transmembrane transport (SLC15A4)

Anatomy Link Frequency macrophages 2 SLC15A4 (Homo sapiens) Fos (Mus musculus)

Pain Link Frequency Relevance Heat Calcium channel 1 100.00 Inflammatory response 1 84.20 sodium channel 5 79.16 cytokine 18 72.96 Inflammation 7 60.24 metalloproteinase 3 50.00 anticonvulsant 2 5.00 tetrodotoxin 1 5.00 fibrosis 1 5.00 Antiepileptic agent 1 5.00

Disease Link Frequency Relevance Heat Multiple Sclerosis 1 86.52 INFLAMMATION 8 83.84 Gingival Overgrowth 10 19.24 Pathologic Processes 2 5.00 Wound Healing 2 5.00 Convulsion 2 5.00 Fibrosis 1 5.00 Periodontal Disease 1 5.00 Sprains And Strains 1 5.00 Hyperplasia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PHT has been reported to inhibit both activation of T-type calcium channels and RANKL-induced expression of c-fos protein in bone marrow-derived macrophages implying that calcium signals play a role in c-fos expression [57].

PHT Negative_regulation (inhibit) of Gene_expression (expression) of c-fos in macrophages associated with calcium channel

1) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.23 Pain Relevance 0.23

General Comments

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