INT33541

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Context Info
Confidence 0.40
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Son) RNA binding (Son) nucleus (Son)
intracellular (Son) cell cycle (Son) DNA binding (Son)
Anatomy Link Frequency
SON 1
Son (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 99.28 Very High Very High Very High
Clonidine 3 97.64 Very High Very High Very High
noradrenaline 10 96.20 Very High Very High Very High
antagonist 3 87.44 High High
Neuropeptide 9 75.32 Quite High
depression 2 72.16 Quite High
cytokine 13 46.08 Quite Low
Neurotransmitter 2 9.56 Low Low
Central nervous system 2 8.12 Low Low
Kinase C 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eating Disorder 1 73.04 Quite High
Depression 2 72.16 Quite High
Pituitary Acth Hypersecretion 1 71.68 Quite High
Hyponatremia 5 69.84 Quite High
Targeted Disruption 10 34.80 Quite Low
Stress 28 6.60 Low Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the alpha 1-agonists phenylephrine and methoxamine also increased the activity of all SON neurons tested whereas application of the alpha 2-agonist clonidine and the beta-agonist isoproterenol had weak and inconsistent effects.
Positive_regulation (increased) of SON in SON associated with agonist and clonidine
1) Confidence 0.40 Published 1986 Journal Brain Res. Section Abstract Doc Link 3008940 Disease Relevance 0 Pain Relevance 0.67
The phospholylation of CRE-binding protein (CREB) is rapidly induced in SON after osmotic stimulus (Shiromani et al. 1995).
Positive_regulation (induced) of SON
2) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.29 Pain Relevance 0.07

General Comments

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