INT33542

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Context Info
Confidence 0.76
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 41
Total Number 41
Disease Relevance 32.47
Pain Relevance 18.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
joint 5
brain 4
macrophage 2
chondrocytes 1
knee joint 1
Il1rn (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 880 100.00 Very High Very High Very High
Inflammation 556 100.00 Very High Very High Very High
antagonist 78 100.00 Very High Very High Very High
Arthritis 1371 99.78 Very High Very High Very High
metalloproteinase 97 99.48 Very High Very High Very High
Paracetamol 32 99.28 Very High Very High Very High
ischemia 52 99.04 Very High Very High Very High
withdrawal 5 99.04 Very High Very High Very High
Central nervous system 172 98.90 Very High Very High Very High
noradrenaline 10 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 582 100.00 Very High Very High Very High
Diabetes Mellitus 36 100.00 Very High Very High Very High
Targeted Disruption 85 99.98 Very High Very High Very High
Arthritis 1502 99.78 Very High Very High Very High
Neuropathic Pain 28 99.76 Very High Very High Very High
Cold Sores 1101 99.62 Very High Very High Very High
Sprains And Strains 52 99.58 Very High Very High Very High
Syndrome 17 99.58 Very High Very High Very High
Systemic Lupus Erythematosus 45 99.30 Very High Very High Very High
Stroke 90 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The largest increase was seen in IL-1Ra gene (Il1rn) expression, which was up regulated 155-fold.
Gene_expression (n) express) of Il1rn
1) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.57 Pain Relevance 0.62
The largest increase was seen in IL-1Ra gene (Il1rn) expression, which was up regulated 155-fold.
Gene_expression (n) express) of IL-1Ra
2) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.57 Pain Relevance 0.62
Based on this calculation, the difference in Il1rn expression between LFD and HFD would actually be larger rather than smaller after infection.
Gene_expression (expression) of Il1rn associated with infection
3) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.44 Pain Relevance 0.14
Acetaminophen (APAP) induced increases in intrahepatic expression of interleukin (IL)-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1ra), when administered intraperitoneally.
Gene_expression (expression) of IL-1 receptor antagonist associated with paracetamol and antagonist
4) Confidence 0.53 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.16 Pain Relevance 0.73
Acetaminophen (APAP) induced increases in intrahepatic expression of interleukin (IL)-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1ra), when administered intraperitoneally.
Gene_expression (expression) of IL-1ra associated with paracetamol and antagonist
5) Confidence 0.53 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.16 Pain Relevance 0.73
In the absence of IRAP expression, there is a complete loss of the Ang IV binding site in the brain.
Gene_expression (expression) of IRAP in brain
6) Confidence 0.48 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.42 Pain Relevance 0.21
Although IRAP was cloned more than a decade ago, the first and only specific, high affinity inhibitors of IRAP that are used to investigate the physiological roles of the enzyme are the peptides Ang IV and LVV-H7.
Gene_expression (cloned) of IRAP
7) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.26 Pain Relevance 0.31
In the present study, we tested the role of IL-1 in neuropathic pain models using two mouse strains impaired in IL-1 signaling: Deletion of the IL-1 receptor type I (IL-1rKO) and transgenic over-expression of the IL-1 receptor antagonist (IL-1raTG).
Gene_expression (over-expression) of IL-1raTG associated with targeted disruption, antagonist, eae and sprains and strains
8) Confidence 0.38 Published 2006 Journal Pain Section Abstract Doc Link 16426759 Disease Relevance 1.62 Pain Relevance 0.87
Morphine-induced analgesia was also extended in strains of mice genetically impaired in IL-1 signaling (mice with transgenic over-expression of IL-1 receptor antagonist, deletion of the IL-1 receptor type I, or deletion of the IL-1 receptor accessory protein).
Gene_expression (over-expression) of antagonist associated with targeted disruption, antagonist, sprains and strains, analgesia and morphine
9) Confidence 0.27 Published 2005 Journal Pain Section Abstract Doc Link 15836969 Disease Relevance 0.42 Pain Relevance 1.99
Mice or rats with lupus-like syndrome, transgenic HLA-B27 expression, nonobese diabetes, and interleukin-1 receptor antagonist (IL-1Ra) deficiency belong to the first category, whereas those with collagen-induced arthritis or experimental autoimmune encephalomyelitis (EAE) as models of RA and multiple sclerosis (MS), respectively, belong to the second category.
Gene_expression (expression) of interleukin-1 receptor antagonist associated with diabetes mellitus, syndrome, rheumatoid arthritis, systemic lupus erythematosus, targeted disruption, multiple sclerosis, antagonist and arthritis
10) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592775 Disease Relevance 1.68 Pain Relevance 0.24
Mice or rats with lupus-like syndrome, transgenic HLA-B27 expression, nonobese diabetes, and interleukin-1 receptor antagonist (IL-1Ra) deficiency belong to the first category, whereas those with collagen-induced arthritis or experimental autoimmune encephalomyelitis (EAE) as models of RA and multiple sclerosis (MS), respectively, belong to the second category.
Gene_expression (expression) of IL-1Ra associated with diabetes mellitus, syndrome, rheumatoid arthritis, systemic lupus erythematosus, targeted disruption, multiple sclerosis, antagonist and arthritis
11) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592775 Disease Relevance 1.68 Pain Relevance 0.24
While the alpha 2-antagonist yohimbine had no consistent influence, the alpha 1-antagonist prazosin blocked or reversed the effects of NA.
Neg (blocked) Gene_expression (blocked) of alpha 1-antagonist associated with antagonist and noradrenaline
12) Confidence 0.22 Published 1986 Journal Brain Res. Section Abstract Doc Link 3008940 Disease Relevance 0 Pain Relevance 0.75
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Gene_expression (levels) of IL-1Ra in Spleen associated with withdrawal
13) Confidence 0.21 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.49
Most of the findings here are based on the experiments involving a transgenic mouse strain with brain-directed overexpression of human IL-1ra, in which the balance between IL-1 and IL-1ra is permanently tipped towards inhibiting IL-1 signalling.
Gene_expression (overexpression) of IL-1ra in brain associated with targeted disruption and sprains and strains
14) Confidence 0.17 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 19258032 Disease Relevance 0.61 Pain Relevance 0.08
Figure 6b shows that IL-1ra was detected in higher amounts in whole joint homogenates than in serum of both nonimmunized wild-type and E/P-selectin mutant mice, but we did not find differences in IL-1ra expression between nonimmunized wild-type and E/P-selectin joint homogenates, suggesting selectin deficiency does not significantly alter IL-1ra expression in the serum or joints.


Gene_expression (expression) of IL-1ra in joint
15) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.65 Pain Relevance 0.24
It was previously reported that mice overexpressing IL-1ra exhibited reduced incidence and severity of CIA, whereas mice deficient in the IL-1ra gene showed accelerated development of arthritis with increased severity [31].
Gene_expression (overexpressing) of IL-1ra associated with arthritis
16) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.31 Pain Relevance 0.63
We also examined the joints of wild-type and E/P-selectin mutant mice for IL-1ra expression normalized to total protein levels.
Gene_expression (expression) of IL-1ra in joints
17) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.43 Pain Relevance 0.20
Figure 6b shows that IL-1ra was detected in higher amounts in whole joint homogenates than in serum of both nonimmunized wild-type and E/P-selectin mutant mice, but we did not find differences in IL-1ra expression between nonimmunized wild-type and E/P-selectin joint homogenates, suggesting selectin deficiency does not significantly alter IL-1ra expression in the serum or joints.


Gene_expression (expression) of IL-1ra in joint
18) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.61 Pain Relevance 0.21
, to be a significant in vivo and in vitro stimulus for murine IL-1ra production [24].
Gene_expression (production) of IL-1ra
19) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.65 Pain Relevance 0.38
We examined the serum of nonimmunized and post-CIA onset E/P-selectin mutant and wild-type mice for IL-1 receptor antagonist (IL-1ra) expression by ELISA.
Gene_expression (expression) of IL-1ra associated with antagonist and arthritis
20) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.41 Pain Relevance 0.22

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