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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpm) plasma membrane (Cpm) nucleus (Cpm)
molecular_function (Cpm) biological_process (Cpm) cytoplasm (Cpm)
Anatomy Link Frequency
IB4 1
Cpm (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 150 95.40 Very High Very High Very High
c fibre 66 92.28 High High
bradykinin 6 79.28 Quite High
Inflammatory mediators 8 78.40 Quite High
Inflammatory response 4 73.04 Quite High
Hyperalgesia 26 50.00 Quite Low
Thermal hyperalgesia 10 37.12 Quite Low
Pain 6 21.52 Low Low
nociceptor 26 8.88 Low Low
unmyelinated 2 8.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 160 95.40 Very High Very High Very High
Neurogenic Inflammation 2 87.12 High High
Pressure And Volume Under Development 12 59.00 Quite High
Targeted Disruption 2 53.60 Quite High
Hyperalgesia 36 50.00 Quite Low
Injury 10 49.52 Quite Low
Neuropathic Pain 6 49.16 Quite Low
Pain 8 21.52 Low Low
Sprains And Strains 6 12.88 Low Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possible mechanism that could be responsible for the increase in the magnitude of the response to heat in IB4-positive CPM fibers is modulation of the M-current.
Regulation (modulation) of CPM in IB4
1) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.55 Pain Relevance 0.32
Interestingly, this change in CPM conduction velocity was not observed in the TRPV-/- mice (naïve = 0.53 +/- 0.01 m/s vs inflamed = 0.51 +/- 0.01 m/s; p value >0.05; student's t-test) mice after inflammation.
Regulation (change) of CPM associated with inflammation
2) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.47 Pain Relevance 0.40

General Comments

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