INT335443

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpm) plasma membrane (Cpm) nucleus (Cpm)
molecular_function (Cpm) biological_process (Cpm) cytoplasm (Cpm)
Anatomy Link Frequency
skin 1
Cpm (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 26 90.08 High High
Inflammation 150 87.60 High High
Inflammatory mediators 8 83.84 Quite High
bradykinin 6 81.36 Quite High
Inflammatory response 4 69.92 Quite High
Lasting pain 2 67.60 Quite High
c fibre 66 62.64 Quite High
qutenza 6 60.44 Quite High
Peripheral nerve injury 2 58.48 Quite High
Thermal hyperalgesia 10 42.56 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 36 90.08 High High
INFLAMMATION 160 87.60 High High
Sprains And Strains 6 87.24 High High
Neurogenic Inflammation 2 84.00 Quite High
Injury 10 76.08 Quite High
Pain 8 67.60 Quite High
Nervous System Injury 6 57.60 Quite High
Pressure And Volume Under Development 12 55.88 Quite High
Targeted Disruption 2 50.48 Quite High
Neuropathic Pain 6 46.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results in wildtype mice strongly suggested that this was a TRPV1-independent process, and additional experiments carried out in the inflamed TRPV1-/- mice confirmed that at least part of the heat sensitization process of CPM-fibers (the decrease in heat threshold) is independent of TRPV1.
Negative_regulation (decrease) of CPM
1) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.76 Pain Relevance 0.54
The M-current has been shown to be present in CPM fibers innervating mouse skin that also contain the mas gene related G-protein coupled receptor D [56].
Negative_regulation (present) of CPM in skin
2) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.53 Pain Relevance 0.38

General Comments

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