INT335482

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ENPP3)
Anatomy Link Frequency
basophils 2
ENPP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 34 89.84 High High
Bioavailability 2 37.04 Quite Low
agonist 14 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 28 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Disease Susceptibility 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Anaphylaxis 2 5.00 Very Low Very Low Very Low
Chronic Disease 2 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quercetin ability to target calmodulin drives to the suggestion that those events inhibited by the flavonoid, i.e. the histamine release and CD63 membrane up-regulation, were presumably related to a Ca++/calmodulin dependent pathway in basophils activated with A23187, while the expression of CD203c, which was not significantly affected by the flavonoid even at its highest dose, might be a calmodulin-independent event.
Neg (not) Regulation (affected) of Gene_expression (expression) of CD203c in basophils
1) Confidence 0.48 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0
In response to calcium ionophore A23187 the expression of both the activation markers CD63 and CD203c was markedly up-regulated, but quercetin exerted a significant inhibitory action, even at nanomolar doses, only on CD63, so dissecting the response of the two activation markers to the ionophore.
Regulation (regulated) of Gene_expression (expression) of CD203c
2) Confidence 0.35 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.23

General Comments

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